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Plekhb1 pleckstrin homology domain containing, family B (evectins) member 1 [ Mus musculus (house mouse) ]

Gene ID: 27276, updated on 6-Sep-2021

Summary

Official Symbol
Plekhb1provided by MGI
Official Full Name
pleckstrin homology domain containing, family B (evectins) member 1provided by MGI
Primary source
MGI:MGI:1351469
See related
Ensembl:ENSMUSG00000030701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PH; PHR1; Phre; evt-; evt-1; Phret1; AI315628
Expression
Biased expression in cerebellum adult (RPKM 133.7), cortex adult (RPKM 82.4) and 6 other tissues See more
Orthologs
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Genomic context

See Plekhb1 in Genome Data Viewer
Location:
7; 7 E2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100291922..100311601, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100643896..100662394, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (107792410..107810908, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L48 Neighboring gene cytochrome c oxidase assembly protein 20B Neighboring gene RAB6A, member RAS oncogene family Neighboring gene predicted gene, 53385 Neighboring gene predicted gene, 35082 Neighboring gene family with sequence similarity 168, member A Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in photoreceptor outer segment TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
pleckstrin homology domain-containing family B member 1
Names
PH domain-containing family B member 1
PH domain-containing protein in retina 1
evectin-1
pleckstrin homology domain retinal protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163182.1NP_001156654.1  pleckstrin homology domain-containing family B member 1 isoform b

    See identical proteins and their annotated locations for NP_001156654.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC124531, BC024756, CD773826
    Consensus CDS
    CCDS52326.1
    UniProtKB/Swiss-Prot
    Q9QYE9
    Related
    ENSMUSP00000102662.3, ENSMUST00000107047.10
    Conserved Domains (2) summary
    cd13265
    Location:20127
    PH_evt; Evectin Pleckstrin homology (PH) domain
    pfam00169
    Location:22126
    PH; PH domain
  2. NM_001163183.1NP_001156655.1  pleckstrin homology domain-containing family B member 1 isoform c

    See identical proteins and their annotated locations for NP_001156655.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 6 both encode isoform c.
    Source sequence(s)
    BC024756, BY284567, CD773826, CX201870
    Consensus CDS
    CCDS52325.1
    UniProtKB/Swiss-Prot
    Q9QYE9
    Related
    ENSMUSP00000111991.3, ENSMUST00000116287.9
    Conserved Domains (1) summary
    cd13265
    Location:1108
    PH_evt; Evectin Pleckstrin homology (PH) domain
  3. NM_001163184.1NP_001156656.1  pleckstrin homology domain-containing family B member 1 isoform d

    See identical proteins and their annotated locations for NP_001156656.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks an internal segment compared to isoform a. Variants 4, 5, and 7 all encode isoform d.
    Source sequence(s)
    AK005102, BY284567, CD773826
    Consensus CDS
    CCDS52324.1
    UniProtKB/Swiss-Prot
    Q9QYE9
    UniProtKB/TrEMBL
    Q3TP62
    Related
    ENSMUSP00000102659.4, ENSMUST00000107044.10
    Conserved Domains (1) summary
    cd13265
    Location:1108
    PH_evt; Evectin Pleckstrin homology (PH) domain
  4. NM_001163185.1NP_001156657.1  pleckstrin homology domain-containing family B member 1 isoform d

    See identical proteins and their annotated locations for NP_001156657.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks an internal segment compared to isoform a. Variants 4, 5, and 7 all encode isoform d.
    Source sequence(s)
    AK005102, BY284567, CD773826
    Consensus CDS
    CCDS52324.1
    UniProtKB/Swiss-Prot
    Q9QYE9
    UniProtKB/TrEMBL
    Q3TP62
    Conserved Domains (1) summary
    cd13265
    Location:1108
    PH_evt; Evectin Pleckstrin homology (PH) domain
  5. NM_001163186.1NP_001156658.1  pleckstrin homology domain-containing family B member 1 isoform c

    See identical proteins and their annotated locations for NP_001156658.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 6 both encode isoform c.
    Source sequence(s)
    BC024756, BY255927, CD773826
    Consensus CDS
    CCDS52325.1
    UniProtKB/Swiss-Prot
    Q9QYE9
    Related
    ENSMUSP00000102660.2, ENSMUST00000107045.9
    Conserved Domains (1) summary
    cd13265
    Location:1108
    PH_evt; Evectin Pleckstrin homology (PH) domain
  6. NM_001163187.1NP_001156659.1  pleckstrin homology domain-containing family B member 1 isoform d

    See identical proteins and their annotated locations for NP_001156659.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks an internal segment compared to isoform a. Variants 4, 5, and 7 all encode isoform d.
    Source sequence(s)
    BC024756, BY255927, CD773826
    Consensus CDS
    CCDS52324.1
    UniProtKB/Swiss-Prot
    Q9QYE9
    UniProtKB/TrEMBL
    Q3TP62
    Related
    ENSMUSP00000102661.2, ENSMUST00000107046.8
    Conserved Domains (1) summary
    cd13265
    Location:1108
    PH_evt; Evectin Pleckstrin homology (PH) domain
  7. NM_001291336.1NP_001278265.1  pleckstrin homology domain-containing family B member 1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence and lacks two alternate exons compared to variant 1, that causes a frameshift. The resulting isoform (e) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AK005102, BY284567, CD776763
    Consensus CDS
    CCDS80756.1
    UniProtKB/Swiss-Prot
    Q9QYE9
    UniProtKB/TrEMBL
    D3YV71
    Related
    ENSMUSP00000102658.2, ENSMUST00000107043.8
    Conserved Domains (1) summary
    cd13265
    Location:197
    PH_evt; Evectin Pleckstrin homology (PH) domain
  8. NM_013746.3NP_038774.1  pleckstrin homology domain-containing family B member 1 isoform a

    See identical proteins and their annotated locations for NP_038774.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC124531, BC024756, CD773826
    Consensus CDS
    CCDS21504.1
    UniProtKB/Swiss-Prot
    Q9QYE9
    Related
    ENSMUSP00000078175.7, ENSMUST00000079176.14
    Conserved Domains (2) summary
    cd13265
    Location:20127
    PH_evt; Evectin Pleckstrin homology (PH) domain
    pfam00169
    Location:22126
    PH; PH domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    100291922..100311601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153147.1XP_036009040.1  pleckstrin homology domain-containing family B member 1 isoform X2

    Conserved Domains (1) summary
    cd13265
    Location:1108
    PH_evt; Evectin Pleckstrin homology (PH) domain
  2. XM_036153149.1XP_036009042.1  pleckstrin homology domain-containing family B member 1 isoform X3

    Conserved Domains (1) summary
    cd13265
    Location:197
    PH_evt; Evectin Pleckstrin homology (PH) domain
  3. XM_006507906.2XP_006507969.1  pleckstrin homology domain-containing family B member 1 isoform X1

    See identical proteins and their annotated locations for XP_006507969.1

    UniProtKB/Swiss-Prot
    Q9QYE9
    Conserved Domains (1) summary
    cd13265
    Location:1108
    PH_evt; Evectin Pleckstrin homology (PH) domain
  4. XM_036153148.1XP_036009041.1  pleckstrin homology domain-containing family B member 1 isoform X3

    Conserved Domains (1) summary
    cd13265
    Location:197
    PH_evt; Evectin Pleckstrin homology (PH) domain
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