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RBMXL2 RBMX like 2 [ Homo sapiens (human) ]

Gene ID: 27288, updated on 5-Mar-2024

Summary

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Official Symbol
RBMXL2provided by HGNC
Official Full Name
RBMX like 2provided by HGNC
Primary source
HGNC:HGNC:17886
See related
Ensembl:ENSG00000170748 MIM:605444; AllianceGenome:HGNC:17886
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNRPGT; HNRNPGT; HNRNPG-T
Summary
This gene belongs to the HNRPG subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind RNAs. This gene is intronless and is thought to be derived from a processed retroposon. However, unlike many retroposon-derived genes, this gene is not a pseudogene. The encoded protein has similarity to HNRPG and RBMY proteins and it is suggested to replace HNRPG protein function during meiotic prophase or act as a germ cell-specific splicing regulator. It primarily localizes to the nuclei of meiotic spermatocytes. This gene is a candidate for autosomal male infertility. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

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Location:
11p15.4
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (7088998..7091148)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (7147733..7149883)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (7110229..7112379)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724711 Neighboring gene zinc finger protein 215 Neighboring gene Sharpr-MPRA regulatory region 9308 Neighboring gene zinc finger protein 214 Neighboring gene NLR family pyrin domain containing 14 Neighboring gene Sharpr-MPRA regulatory region 5166 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:7098372-7098571 Neighboring gene Sharpr-MPRA regulatory region 4980 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3108 Neighboring gene microRNA 302e Neighboring gene NANOG hESC enhancer GRCh37_chr11:7296267-7296768 Neighboring gene synaptotagmin 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4359 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:7438930-7440129 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4360 Neighboring gene Sharpr-MPRA regulatory region 13298 Neighboring gene NANOG hESC enhancer GRCh37_chr11:7472795-7473306 Neighboring gene SYT9 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Localization of the germ cell-specific protein, hnRNP G-T, in testicular biopsies of azoospermic men. Maymon BB, et al. Acta Histochem, 2002. PMID 12389739
  2. An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene. Elliott DJ, et al. Hum Mol Genet, 2000 Sep 1. PMID 10958650
  3. Expression levels of hnRNP G and hTra2-beta1 correlate with opposite outcomes in endometrial cancer biology. Ouyang YQ, et al. Int J Cancer, 2011 May 1. PMID 20607830
  4. Novel domains in the hnRNP G/RBMX protein with distinct roles in RNA binding and targeting nascent transcripts. Kanhoush R, et al. Nucleus, 2010 Jan-Feb. PMID 21327109, Free PMC Article
  5. The germ cell nuclear proteins hnRNP G-T and RBMY activate a testis-specific exon. Liu Y, et al. PLoS Genet, 2009 Nov. PMID 19893608, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The initial recruitment of hnRNP G to nascent pre-mRNAs is independent of its sequence-specific RNA binding properties.
    Title: Novel domains in the hnRNP G/RBMX protein with distinct roles in RNA binding and targeting nascent transcripts.
  2. nuclear hnRNP G level as well as hTra2-beta1 level were independent prognostic factors for endometrial cancer progression-free survival
    Title: Expression levels of hnRNP G and hTra2-beta1 correlate with opposite outcomes in endometrial cancer biology.
  3. germ cell-specific RBMY and hnRNP G-T proteins were more efficient in stimulating TLE4-T incorporation than somatically expressed hnRNP G protein.
    Title: The germ cell nuclear proteins hnRNP G-T and RBMY activate a testis-specific exon.
  4. Heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) is a germ cell-specific protein expressed most prominently during meiosis
    Title: Localization of the germ cell-specific protein, hnRNP G-T, in testicular biopsies of azoospermic men.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U12-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding motif protein, X-linked-like-2
Names
RNA binding motif protein, X-linked like 2
heterogeneous nuclear ribonucleoprotein G T
hnRNP G-T
testes-specific heterogenous nuclear ribonucleoprotein G-T
testis-specific heterogeneous nuclear ribonucleoprotein G-T

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014469.5 → NP_055284.3  RNA-binding motif protein, X-linked-like-2

    See identical proteins and their annotated locations for NP_055284.3

    Status: REVIEWED

    Source sequence(s)
    AC100875
    Consensus CDS
    CCDS7777.1
    UniProtKB/Swiss-Prot
    O75526, Q6PEZ2, Q9NQU0
    UniProtKB/TrEMBL
    A8K8A6
    Related
    ENSP00000304139.5, ENST00000306904.7
    Conserved Domains (3) summary
    COG0724
    Location:9 → 81
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12382
    Location:7 → 86
    RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
    pfam08081
    Location:173 → 217
    RBM1CTR; RBM1CTR (NUC064) family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    7088998..7091148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    7147733..7149883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75526.3 GenPept UniProtKB/Swiss-Prot:O75526

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