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GLI4 GLI family zinc finger 4 [ Homo sapiens (human) ]

Gene ID: 2738, updated on 11-Apr-2024

Summary

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Official Symbol
GLI4provided by HGNC
Official Full Name
GLI family zinc finger 4provided by HGNC
Primary source
HGNC:HGNC:4320
See related
Ensembl:ENSG00000250571 MIM:165280; AllianceGenome:HGNC:4320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HKR4; ZNF928
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 5.3), spleen (RPKM 4.2) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
8q24.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (143267445..143276931)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (144414875..144424319)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144349615..144359101)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144332854-144333354 Neighboring gene ZFP41 zinc finger protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19613 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144350631-144351453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144353055-144353555 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144357207-144357850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144357851-144358494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144361711-144362353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28068 Neighboring gene MYC-induced long non-coding RNA Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144373076-144373651 Neighboring gene zinc finger protein 696

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Assignment of the gene encoding human Krüppel-related zinc finger protein 4 (GLI4) to 8q24.3 by fluorescent in situ hybridization. Kas K, et al. Cytogenet Cell Genet, 1996. PMID 8641133
  2. The GLI-Kruppel family of human genes. Ruppert JM, et al. Mol Cell Biol, 1988 Aug. PMID 2850480, Free PMC Article
  3. DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy. Nowak M, et al. J Cell Sci, 2019 Sep 6. PMID 31391242
  4. Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes. Davis ZH, et al. Mol Cell, 2015 Jan 22. PMID 25544563, Free PMC Article
  5. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein GLI4
Names
GLI-Kruppel family member GLI4 (oncogene HKR4)
glioma-associated oncogene family zinc finger 4
krueppel-related zinc finger protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138465.4 → NP_612474.1  zinc finger protein GLI4

    See identical proteins and their annotated locations for NP_612474.1

    Status: VALIDATED

    Source sequence(s)
    AI829114, BC014165, BI761835
    Consensus CDS
    CCDS6398.1
    UniProtKB/Swiss-Prot
    P10075, Q96CK9
    Related
    ENSP00000345024.1, ENST00000340042.2
    Conserved Domains (4) summary
    COG5048
    Location:181 → 343
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:241 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:183 → 205
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:281 → 304
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    143267445..143276931
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    144414875..144424319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10075.2 GenPept UniProtKB/Swiss-Prot:P10075

Gene LinkOut

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