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Dusp13b dual specificity phosphatase 13B [ Mus musculus (house mouse) ]

Gene ID: 27389, updated on 5-Mar-2024

Summary

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Official Symbol
Dusp13bprovided by MGI
Official Full Name
dual specificity phosphatase 13Bprovided by MGI
Primary source
MGI:MGI:1351599
See related
Ensembl:ENSMUSG00000021768 AllianceGenome:MGI:1351599
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MDSP; TMDP; Dusp13; Gm1203; DUSP13A; TS-DSP6; LMW-DSP6
Summary
Enables protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in dephosphorylation and negative regulation of MAPK cascade. Predicted to be active in cytoplasm. Is expressed in ductus deferens; epididymis; ileum; and testis. Orthologous to human DUSP13 (dual specificity phosphatase 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 101.6) See more
Orthologs
human all
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Genomic context

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Location:
14 A3; 14 11.85 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (21783463..21792947, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (21733395..21748651, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8945 Neighboring gene STARR-positive B cell enhancer ABC_E605 Neighboring gene STARR-positive B cell enhancer ABC_E4100 Neighboring gene K(lysine) acetyltransferase 6B Neighboring gene STARR-seq mESC enhancer starr_36143 Neighboring gene STARR-seq mESC enhancer starr_36148 Neighboring gene VISTA enhancer mm1600 Neighboring gene dual specificity phosphatase 29 Neighboring gene STARR-positive B cell enhancer ABC_E10820 Neighboring gene predicted gene 15935 Neighboring gene dual specificity phosphatase 13a Neighboring gene sterile alpha motif domain containing 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis. Nakamura K, et al. Biochem J, 1999 Dec 15. PMID 10585869, Free PMC Article
  2. Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2. Chen HH, et al. J Biol Chem, 2004 Oct 1. PMID 15252030
  3. A novel phosphatase family, structurally related to dual-specificity phosphatases, that displays unique amino acid sequence and substrate specificity. Romá-Mateo C, et al. J Mol Biol, 2007 Dec 7. PMID 17976645
  4. Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance. Almind K, et al. Diabetes, 2003 Jun. PMID 12765967
  5. A growing family of dual specificity phosphatases with low molecular masses. Aoki N, et al. J Biochem, 2001 Jul. PMID 11432789

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MAP kinase phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dual specificity protein phosphatase 13B
Names
Dsp13-like protein
dual specificity phosphatase 13
dual specificity protein phosphatase 13
dual-specificity tyrosine phosphatase TS-DSP6
muscle-restricted DSP
testis and skeletal muscle-specific dual specificity phosphatase
testis- and skeletal muscle-specific DSP
NP_001361004.1
NP_001361006.1
NP_001361007.1
NP_001361008.1
NP_038877.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374075.1 → NP_001361004.1  dual specificity protein phosphatase 13B isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC151533
    Consensus CDS
    CCDS88593.1
    UniProtKB/TrEMBL
    Z4YLI2
    Related
    ENSMUSP00000112552.3, ENSMUST00000119866.9
    Conserved Domains (1) summary
    cl28904
    Location:146 → 309
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. NM_001374077.1 → NP_001361006.1  dual specificity protein phosphatase 13B isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform 4.
    Source sequence(s)
    AC151533
    Consensus CDS
    CCDS88592.1
    UniProtKB/Swiss-Prot
    Q497R2, Q9QYJ7
    UniProtKB/TrEMBL
    V9GXA1
    Related
    ENSMUSP00000138972.2, ENSMUST00000184703.8
    Conserved Domains (1) summary
    cl28904
    Location:28 → 191
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  3. NM_001374078.1 → NP_001361007.1  dual specificity protein phosphatase 13B isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform 4.
    Source sequence(s)
    AC151533
    Consensus CDS
    CCDS88592.1
    UniProtKB/Swiss-Prot
    Q497R2, Q9QYJ7
    UniProtKB/TrEMBL
    V9GXA1
    Conserved Domains (1) summary
    cl28904
    Location:28 → 191
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  4. NM_001374079.1 → NP_001361008.1  dual specificity protein phosphatase 13B isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform 4.
    Source sequence(s)
    AC151533, BC100421
    UniProtKB/Swiss-Prot
    Q497R2, Q9QYJ7
    UniProtKB/TrEMBL
    V9GXA1
    Related
    ENSMUSP00000113985.2, ENSMUST00000120984.9
    Conserved Domains (1) summary
    cl28904
    Location:28 → 191
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  5. NM_013849.3 → NP_038877.2  dual specificity protein phosphatase 13B isoform 2

    See identical proteins and their annotated locations for NP_038877.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes isoform 2 (also called TMDP) and is found only in testis.
    Source sequence(s)
    AB027003, AK006247, BX629730
    Consensus CDS
    CCDS26864.1
    UniProtKB/TrEMBL
    Q7TNW3, Q9DA25
    Related
    ENSMUSP00000113305.2, ENSMUST00000120956.8
    Conserved Domains (1) summary
    cd00127
    Location:110 → 253
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    21783463..21792947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYJ7.1 GenPept UniProtKB/Swiss-Prot:Q9QYJ7

Gene LinkOut

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