GLO1 glyoxalase I [Homo sapiens (human)] - Gene

Summary

Official Symbol: GLO1provided by HGNC
Official Full Name: glyoxalase Iprovided by HGNC
Primary source: HGNC:HGNC:4323
See related: Ensembl:ENSG00000124767 MIM:138750; AllianceGenome:HGNC:4323
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GLYI; GLOD1; HEL-S-74
Summary: The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in prostate (RPKM 115.6), duodenum (RPKM 59.9) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p21.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (38675925..38703145, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (38500476..38527717, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (38643701..38670921, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association between GLO1 variants and gestational diabetes mellitus susceptibility in a Chinese population: a preliminary study.
Title: Association between GLO1 variants and gestational diabetes mellitus susceptibility in a Chinese population: a preliminary study.
MiR-205-3p suppresses bladder cancer progression via GLO1 mediated P38/ERK activation.
Title: MiR-205-3p suppresses bladder cancer progression via GLO1 mediated P38/ERK activation.
The genetic polymorphisms and activity of glyoxalase 1 as a risk factor for acute coronary syndrome in South Indians with type 2 diabetes mellitus.
Title: The genetic polymorphisms and activity of glyoxalase 1 as a risk factor for acute coronary syndrome in South Indians with type 2 diabetes mellitus.
H3K27 acetylation activated long noncoding RNA RP11-162G10.5 promotes breast cancer progression via the YBX1/GLO1 axis.
Title: H3K27 acetylation activated long noncoding RNA RP11-162G10.5 promotes breast cancer progression via the YBX1/GLO1 axis.
High expression of GLO1 indicates unfavorable clinical outcomes in glioma patients.
Title: High expression of GLO1 indicates unfavorable clinical outcomes in glioma patients.
The activity of glyoxylase 1 is regulated by glucose-responsive phosphorylation on Tyr136.
Title: The activity of glyoxylase 1 is regulated by glucose-responsive phosphorylation on Tyr136.
Emerging Glycation-Based Therapeutics-Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors.
Title: Emerging Glycation-Based Therapeutics-Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors.
Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males.
Title: Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males.
GLO 1 and PKClambda Regulate ALDH1-positive Breast Cancer Stem Cell Survival.
Title: GLO 1 and PKCλ Regulate ALDH1-positive Breast Cancer Stem Cell Survival.
Glyoxalase 1 expression analysis by immunohistochemistry in breast cancer.
Title: Glyoxalase 1 expression analysis by immunohistochemistry in breast cancer.

Submit: New GeneRIF Correction See all GeneRIFs (114)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of glyoxalase I (GLO1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH68098 (e-PCR)
- UniSTS:40983

PMC310739P4 (e-PCR)
- UniSTS:272667

RH46862 (e-PCR)
- UniSTS:47709

SHGC-31456 (e-PCR)
- UniSTS:35963

SHGC-83840 (e-PCR)
- UniSTS:101818

G62072 (e-PCR)
- UniSTS:139195

WI-19791 (e-PCR)
- UniSTS:13022

STS-D13315 (e-PCR)
- UniSTS:10489

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables lactoylglutathione lyase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in glutathione metabolic process	IEA Inferred from Electronic Annotation more info
involved_in methylglyoxal metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in osteoclast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: lactoylglutathione lyase

Names: S-D-lactoylglutathione methylglyoxal lyase; aldoketomutase; epididymis secretory protein Li 74; glx I; glyoxalase domain containing 1; ketone-aldehyde mutase; lactoyl glutathione lyase; methylglyoxalase

NP_006699.2

EC 4.4.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.