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Mrpl39 mitochondrial ribosomal protein L39 [ Mus musculus (house mouse) ]

Gene ID: 27393, updated on 5-Mar-2024

Summary

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Official Symbol
Mrpl39provided by MGI
Official Full Name
mitochondrial ribosomal protein L39provided by MGI
Primary source
MGI:MGI:1351620
See related
Ensembl:ENSMUSG00000022889 AllianceGenome:MGI:1351620
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ORF22; Rpml5; MRP-L5; C21orf8
Summary
Predicted to be a structural constituent of ribosome. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; genitourinary system; gut; nervous system; and sensory organ. Orthologous to human MRPL39 (mitochondrial ribosomal protein L39). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 16.9), CNS E11.5 (RPKM 11.7) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 C3.3; 16 46.92 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (84515068..84532261, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (84718281..84735244, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930529L06 gene Neighboring gene STARR-positive B cell enhancer ABC_E3170 Neighboring gene STARR-positive B cell enhancer ABC_E10920 Neighboring gene STARR-positive B cell enhancer ABC_E262 Neighboring gene Mir155 host gene (non-protein coding) Neighboring gene microRNA 155 Neighboring gene STARR-positive B cell enhancer ABC_E10921 Neighboring gene predicted gene, 26153 Neighboring gene predicted gene, 32202

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences. O'Brien TW, et al. J Biol Chem, 1999 Dec 17. PMID 10593885
  2. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
  3. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
  4. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
  5. Human chromosome 21 gene expression atlas in the mouse. Reymond A, et al. Nature, 2002 Dec 5. PMID 12466854

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within mitochondrial genome maintenance TAS
Traceable Author Statement
more info
 PubMed 
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within translation ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial large ribosomal subunit ISA
Inferred from Sequence Alignment
more info
 PubMed 
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein mL39
Names
39S ribosomal protein L39, mitochondrial
L39mt
MRP-L39
ribosomal protein, mitochondrial, L5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384093.1 → NP_001371022.1  large ribosomal subunit protein mL39 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT027693
    Conserved Domains (1) summary
    PLN02908
    Location:27 → 270
    PLN02908; threonyl-tRNA synthetase

  2. NM_001384095.1 → NP_001371024.1  large ribosomal subunit protein mL39 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT027693
    UniProtKB/TrEMBL
    Q8CCX9
    Conserved Domains (1) summary
    PLN02908
    Location:27 → 270
    PLN02908; threonyl-tRNA synthetase

  3. NM_001384096.1 → NP_001371025.1  large ribosomal subunit protein mL39 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT027693
    Conserved Domains (1) summary
    PRK00413
    Location:4 → 161
    thrS; threonyl-tRNA synthetase; Reviewed

  4. NM_017404.5 → NP_059100.3  large ribosomal subunit protein mL39 isoform 1

    See identical proteins and their annotated locations for NP_059100.3

    Status: VALIDATED

    Source sequence(s)
    AK007681, CT027693
    Consensus CDS
    CCDS57035.1
    UniProtKB/Swiss-Prot
    A6X954, Q91YK5, Q9D8U5, Q9JKF7
    UniProtKB/TrEMBL
    Q8CCX9
    Related
    ENSMUSP00000112283.2, ENSMUST00000116584.2
    Conserved Domains (1) summary
    cd01667
    Location:73 → 127
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    84515068..84532261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159970.1 → XP_036015863.1  large ribosomal subunit protein mL39 isoform X1

    Conserved Domains (2) summary
    PLN02908
    Location:144 → 316
    PLN02908; threonyl-tRNA synthetase
    cl28922
    Location:63 → 171
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. XM_017317025.3 → XP_017172514.1  large ribosomal subunit protein mL39 isoform X4

    Conserved Domains (1) summary
    PRK00413
    Location:4 → 161
    thrS; threonyl-tRNA synthetase; Reviewed

  3. XM_036159972.1 → XP_036015865.1  large ribosomal subunit protein mL39 isoform X3

    Conserved Domains (2) summary
    PLN02908
    Location:144 → 316
    PLN02908; threonyl-tRNA synthetase
    cl28922
    Location:63 → 171
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  4. XM_036159971.1 → XP_036015864.1  large ribosomal subunit protein mL39 isoform X2

    Conserved Domains (2) summary
    PLN02908
    Location:144 → 316
    PLN02908; threonyl-tRNA synthetase
    cl28922
    Location:63 → 171
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JKF7.4 GenPept UniProtKB/Swiss-Prot:Q9JKF7

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