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Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 [ Mus musculus (house mouse) ]

Gene ID: 27400, updated on 6-May-2021

Summary

Official Symbol
Hsd17b6provided by MGI
Official Full Name
hydroxysteroid (17-beta) dehydrogenase 6provided by MGI
Primary source
MGI:MGI:1351670
See related
Ensembl:ENSMUSG00000025396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rdh; Rdh8; Hsd17b; Hsd17b9; 17betaHS; 17betaHSD9
Expression
Biased expression in liver adult (RPKM 99.6), duodenum adult (RPKM 16.6) and 3 other tissues See more
Orthologs
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Genomic context

See Hsd17b6 in Genome Data Viewer
Location:
10; 10 D3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127826800..127843517, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127990931..128007648, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (127427992..127444564, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23996 Neighboring gene ring finger protein 181 pseudogene Neighboring gene small nuclear ribonucleoprotein D2 pseudogene Neighboring gene DNA primase, p49 subunit

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in brexanolone catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
17-beta-hydroxysteroid dehydrogenase type 6
Names
17-beta-HSD 6
17-beta-HSD6
17-beta-HSD9
3-alpha->beta-HSE
3-alpha->beta-hydroxysteroid epimerase
hydroxysteroid (17-beta) dehydrogenase 9
oxidative 3-alpha hydroxysteroid dehydrogenase
NP_001346306.1
NP_038814.1
XP_011241766.1
XP_011241767.1
XP_011241769.1
XP_011241770.1
XP_030100965.1
XP_030100966.1
XP_030100967.1
XP_030100968.1
XP_030100969.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359377.1NP_001346306.1  17-beta-hydroxysteroid dehydrogenase type 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131120, AK008212
    Consensus CDS
    CCDS24257.1
    Related
    ENSMUSP00000151661.2, ENSMUST00000219183.2
    Conserved Domains (1) summary
    cl21454
    Location:30306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_013786.3NP_038814.1  17-beta-hydroxysteroid dehydrogenase type 6 precursor

    See identical proteins and their annotated locations for NP_038814.1

    Status: VALIDATED

    Source sequence(s)
    AC131120, AK008212
    Consensus CDS
    CCDS24257.1
    UniProtKB/Swiss-Prot
    Q9R092
    Related
    ENSMUSP00000151556.2, ENSMUST00000219447.2
    Conserved Domains (1) summary
    cl21454
    Location:30306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127826800..127843517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243465.3XP_011241767.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

    See identical proteins and their annotated locations for XP_011241767.1

    UniProtKB/Swiss-Prot
    Q9R092
    Conserved Domains (1) summary
    cl21454
    Location:30306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_011243464.3XP_011241766.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

    See identical proteins and their annotated locations for XP_011241766.1

    UniProtKB/Swiss-Prot
    Q9R092
    Conserved Domains (1) summary
    cl21454
    Location:30306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. XM_030245105.1XP_030100965.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:30306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. XM_030245108.1XP_030100968.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:30306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  5. XM_030245106.1XP_030100966.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:30306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  6. XM_030245107.1XP_030100967.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:30306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  7. XM_011243467.3XP_011241769.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

    See identical proteins and their annotated locations for XP_011241769.1

    UniProtKB/Swiss-Prot
    Q9R092
    Conserved Domains (1) summary
    cl21454
    Location:30306
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  8. XM_030245109.1XP_030100969.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:30262
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  9. XM_011243468.3XP_011241770.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:30262
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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