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Nrep neuronal regeneration related protein [ Mus musculus (house mouse) ]

Gene ID: 27528, updated on 5-Mar-2024

Summary

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Official Symbol
Nrepprovided by MGI
Official Full Name
neuronal regeneration related proteinprovided by MGI
Primary source
MGI:MGI:99444
See related
Ensembl:ENSMUSG00000042834 AllianceGenome:MGI:99444
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Harp; P311; PTZ17; SEZ17; D0H4S114
Summary
Acts upstream of or within regulation of transforming growth factor beta receptor signaling pathway. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including lung; nervous system; otocyst; and retina. Orthologous to human NREP (neuronal regeneration related protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 316.2), whole brain E14.5 (RPKM 274.8) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Nrep in Genome Data Viewer
Location:
18 B1; 18 18.18 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (33570072..33597444, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (33437019..33464365, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41683 Neighboring gene VISTA enhancer mm76 Neighboring gene predicted gene, 46640 Neighboring gene STARR-seq mESC enhancer starr_44167 Neighboring gene O-sialoglycoprotein endopeptidase pseudogene Neighboring gene STARR-seq mESC enhancer starr_44168 Neighboring gene predicted gene 10549 Neighboring gene predicted gene, 41684 Neighboring gene VISTA enhancer mm15 Neighboring gene STARR-seq mESC enhancer starr_44170 Neighboring gene STARR-seq mESC enhancer starr_44172 Neighboring gene predicted gene, 54016

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. P311, a novel intrinsically disordered protein, regulates adipocyte development. Nunez S, et al. Biochem Biophys Res Commun, 2019 Jul 12. PMID 31146912, Free PMC Article
  2. Reconstruction and Functional Annotation of P311 Protein-Protein Interaction Network Reveals Its New Functions. Wang S, et al. Front Genet, 2019. PMID 30838032, Free PMC Article
  3. P311 Deficiency Leads to Attenuated Angiogenesis in Cutaneous Wound Healing. Wang S, et al. Front Physiol, 2017. PMID 29270129, Free PMC Article
  4. P311 modulates hepatic stellate cells migration. Guimarães EL, et al. Liver Int, 2015 Apr. PMID 25243526
  5. Blood pressure homeostasis is maintained by a P311-TGF-β axis. Badri KR, et al. J Clin Invest, 2013 Oct. PMID 24091331, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. P311 regulates distal lung development via its interaction with several binding proteins.
    Title: P311 regulates distal lung development via its interaction with several binding proteins.
  2. Butyrate alleviates diabetic kidney disease by mediating the miR-7a-5p/P311/TGF-beta1 pathway.
    Title: Butyrate alleviates diabetic kidney disease by mediating the miR-7a-5p/P311/TGF-β1 pathway.
  3. Neuronal regeneration related protein (P311) overexpression enhanced adipogenic differentiation of 3T3-L1 cells.
    Title: P311, a novel intrinsically disordered protein, regulates adipocyte development.
  4. The essential function of P311 in TGF-beta-mediated lung fibrosis.P311 regulates TGF-beta1, TGF-beta2 and TGF-beta3 translation in the lung fibrosis.
    Title: P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth Factor-β1, -β2, and -β3 Translation.
  5. P311 is a novel TGFbeta1/Smad signaling-mediated regulator of transdifferentiation in epidermal stem cells during cutaneous wound healing.
    Title: P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor β1 expression.
  6. P311 could accelerate skin wound reepithelialization by promoting the migration of Epidermal Stem Cell through RhoA and Rac1 activation.
    Title: P311 Accelerates Skin Wound Reepithelialization by Promoting Epidermal Stem Cell Migration Through RhoA and Rac1 Activation.
  7. These studies demonstrate that P311 is required for the production of normal cutaneous scars
    Title: Neuronal Protein 3.1 Deficiency Leads to Reduced Cutaneous Scar Collagen Deposition and Tensile Strength due to Impaired Transforming Growth Factor-β1 to -β3 Translation.
  8. P311 plays a key role in renal fibrosis via TGFbeta1/Smad signaling, which could be a novel target for the management of renal fibrosis.
    Title: P311 promotes renal fibrosis via TGFβ1/Smad signaling.
  9. P311 is central to reactive oxygen species-mediated hepatic stellate cell migration induced by different chemokines.
    Title: P311 modulates hepatic stellate cells migration.
  10. P311 is the first protein identified to modulate TGF-beta translation and the first pan-regulator of TGF-beta expression.
    Title: Blood pressure homeostasis is maintained by a P311-TGF-β axis.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon regeneration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neuronal regeneration-related protein
Names
high-altitude regulated protein
neuronal protein 3.1
protein p311

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109988.1 → NP_001103458.1  neuronal regeneration-related protein

    See identical proteins and their annotated locations for NP_001103458.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AC115117, AK020629
    Consensus CDS
    CCDS37756.1
    UniProtKB/Swiss-Prot
    Q07475
    UniProtKB/TrEMBL
    Q542Q5
    Related
    ENSMUSP00000130297.2, ENSMUST00000168890.2
    Conserved Domains (1) summary
    pfam11092
    Location:3 → 68
    Alveol-reg_P311; Neuronal protein 3.1 (p311)

  2. NM_001109989.2 → NP_001103459.1  neuronal regeneration-related protein

    See identical proteins and their annotated locations for NP_001103459.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AC115117, CX768079
    Consensus CDS
    CCDS37756.1
    UniProtKB/Swiss-Prot
    Q07475
    UniProtKB/TrEMBL
    Q542Q5
    Related
    ENSMUSP00000157912.2, ENSMUST00000237066.2
    Conserved Domains (1) summary
    pfam11092
    Location:3 → 68
    Alveol-reg_P311; Neuronal protein 3.1 (p311)

  3. NM_001267717.1 → NP_001254646.1  neuronal regeneration-related protein

    See identical proteins and their annotated locations for NP_001254646.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AC115117
    Consensus CDS
    CCDS37756.1
    UniProtKB/Swiss-Prot
    Q07475
    UniProtKB/TrEMBL
    Q542Q5
    Conserved Domains (1) summary
    pfam11092
    Location:3 → 68
    Alveol-reg_P311; Neuronal protein 3.1 (p311)

  4. NM_053078.4 → NP_444308.1  neuronal regeneration-related protein

    See identical proteins and their annotated locations for NP_444308.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein. Variants 1, 2, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AK048361, AV321356, CJ148521
    Consensus CDS
    CCDS37756.1
    UniProtKB/Swiss-Prot
    Q07475
    UniProtKB/TrEMBL
    Q542Q5
    Related
    ENSMUSP00000058132.9, ENSMUST00000051087.16
    Conserved Domains (1) summary
    pfam11092
    Location:3 → 68
    Alveol-reg_P311; Neuronal protein 3.1 (p311)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    33570072..33597444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250488.2 → XP_030106348.1  neuronal regeneration-related protein isoform X1

    UniProtKB/Swiss-Prot
    Q07475
    UniProtKB/TrEMBL
    Q542Q5
    Conserved Domains (1) summary
    pfam11092
    Location:3 → 68
    Alveol-reg_P311; Neuronal protein 3.1 (p311)

  2. XM_036161164.1 → XP_036017057.1  neuronal regeneration-related protein isoform X1

    UniProtKB/Swiss-Prot
    Q07475
    UniProtKB/TrEMBL
    Q542Q5
    Conserved Domains (1) summary
    pfam11092
    Location:3 → 68
    Alveol-reg_P311; Neuronal protein 3.1 (p311)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07475.1 GenPept UniProtKB/Swiss-Prot:Q07475

Gene LinkOut

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