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Slc9a5 solute carrier family 9 (sodium/hydrogen exchanger), member 5 [ Mus musculus (house mouse) ]

Gene ID: 277973, updated on 5-Mar-2024

Summary

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Official Symbol
Slc9a5provided by MGI
Official Full Name
solute carrier family 9 (sodium/hydrogen exchanger), member 5provided by MGI
Primary source
MGI:MGI:2685542
See related
Ensembl:ENSMUSG00000014786 AllianceGenome:MGI:2685542
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm696; NHE-5
Summary
Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in inorganic cation transmembrane transport and regulation of intracellular pH. Predicted to be active in plasma membrane. Is expressed in brain. Human ortholog(s) of this gene implicated in end stage renal disease. Orthologous to human SLC9A5 (solute carrier family 9 member A5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 13.3), limb E14.5 (RPKM 12.5) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Slc9a5 in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106074782..106095979)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105348156..105369881)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11746 Neighboring gene transmembrane protein 208 Neighboring gene formin homology 2 domain containing 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:107871965-107872074 Neighboring gene predicted gene, 46049 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 4 Neighboring gene potassium channel tetramerisation domain containing 19 Neighboring gene leucine rich repeat containing 36

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nhe5 deficiency enhances learning and memory via upregulating Bdnf/TrkB signaling in mice. Chen X, et al. Am J Med Genet B Neuropsychiatr Genet, 2017 Dec. PMID 28981195
  2. The Na(+)/H (+) exchanger NHE5 is sorted to discrete intracellular vesicles in the central and peripheral nervous systems. Lukashova V, et al. Adv Exp Med Biol, 2013. PMID 23224898
  3. Activation of AMP-activated protein kinase regulates hippocampal neuronal pH by recruiting Na(+)/H(+) exchanger NHE5 to the cell surface. Jinadasa T, et al. J Biol Chem, 2014 Jul 25. PMID 24936055, Free PMC Article
  4. NHE1 is the sodium-hydrogen exchanger active in acute intracellular pH regulation in preimplantation mouse embryos. Siyanov V, et al. Biol Reprod, 2013 Jun. PMID 23677982
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nhe5 deficiency is associated with enhanced learning and memory by upregulating Bdnf and TrkB signaling.
    Title: Nhe5 deficiency enhances learning and memory via upregulating Bdnf/TrkB signaling in mice.
  2. These data reveal a unique role for AMPK and NHE5 in regulating the pH homeostasis of hippocampal neurons during metabolic stress.
    Title: Activation of AMP-activated protein kinase regulates hippocampal neuronal pH by recruiting Na(+)/H(+) exchanger NHE5 to the cell surface.
  3. NHE5 partitions into a unique vesicular pool in neurons that shares some characteristics of recycling endosomes where it may serve as an important regulated store of functional transporters required to maintain cytoplasmic pH homeostasis.
    Title: The Na(+)/H (+) exchanger NHE5 is sorted to discrete intracellular vesicles in the central and peripheral nervous systems.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables arrestin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of intracellular pH ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of pH IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron spine ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sodium/hydrogen exchanger 5
Names
Na(+)/H(+) exchanger 5
sodium/hydrogen exchanger
solute carrier family 9 member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081332.2 → NP_001074801.1  sodium/hydrogen exchanger 5 precursor

    See identical proteins and their annotated locations for NP_001074801.1

    Status: VALIDATED

    Source sequence(s)
    AC124584
    Consensus CDS
    CCDS40457.1
    UniProtKB/Swiss-Prot
    B2RXE2
    Related
    ENSMUSP00000072893.6, ENSMUST00000073149.7
    Conserved Domains (2) summary
    TIGR00840
    Location:44 → 633
    b_cpa1; sodium/hydrogen exchanger 3
    pfam00999
    Location:53 → 458
    Na_H_Exchanger; Sodium/hydrogen exchanger family

RNA

  1. NR_175833.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124584

  2. NR_175834.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124584

  3. NR_175835.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124584

  4. NR_175836.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124584

  5. NR_175837.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124584

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106074782..106095979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531067.5 → XP_006531130.1  sodium/hydrogen exchanger 5 isoform X4

    Conserved Domains (1) summary
    TIGR00840
    Location:5 → 649
    b_cpa1; sodium/hydrogen exchanger 3

  2. XM_006531064.4 → XP_006531127.1  sodium/hydrogen exchanger 5 isoform X1

    Conserved Domains (1) summary
    TIGR00840
    Location:44 → 706
    b_cpa1; sodium/hydrogen exchanger 3

  3. XM_006531065.4 → XP_006531128.1  sodium/hydrogen exchanger 5 isoform X2

    Conserved Domains (1) summary
    TIGR00840
    Location:44 → 706
    b_cpa1; sodium/hydrogen exchanger 3

  4. XM_006531066.4 → XP_006531129.1  sodium/hydrogen exchanger 5 isoform X3

    Conserved Domains (1) summary
    TIGR00840
    Location:44 → 670
    b_cpa1; sodium/hydrogen exchanger 3

  5. XM_017312849.3 → XP_017168338.1  sodium/hydrogen exchanger 5 isoform X5

    Conserved Domains (1) summary
    TIGR00840
    Location:44 → 633
    b_cpa1; sodium/hydrogen exchanger 3

  6. XM_006531069.2 → XP_006531132.1  sodium/hydrogen exchanger 5 isoform X6

    Conserved Domains (1) summary
    TIGR00840
    Location:1 → 408
    b_cpa1; sodium/hydrogen exchanger 3

RNA

  1. XR_387750.4 RNA Sequence

  2. XR_003947300.2 RNA Sequence

  3. XR_004934839.1 RNA Sequence

  4. XR_003947302.2 RNA Sequence

  5. XR_003947303.2 RNA Sequence

  6. XR_004934838.1 RNA Sequence

  7. XR_003947298.2 RNA Sequence

  8. XR_387749.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RXE2.1 GenPept UniProtKB/Swiss-Prot:B2RXE2

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