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Prpf19 pre-mRNA processing factor 19 [ Mus musculus (house mouse) ]

Gene ID: 28000, updated on 22-Aug-2021

Summary

Official Symbol
Prpf19provided by MGI
Official Full Name
pre-mRNA processing factor 19provided by MGI
Primary source
MGI:MGI:106247
See related
Ensembl:ENSMUSG00000024735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P; S; Pr; PSO4; Snev; Prp19; NMP200; AA617263; AL024362; D19Wsu55; D19Wsu55e
Expression
Ubiquitous expression in ovary adult (RPKM 53.7), adrenal adult (RPKM 44.5) and 28 other tissues See more
Orthologs
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Genomic context

See Prpf19 in Genome Data Viewer
Location:
19 A; 19 7.33 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10872595..10886923)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10895231..10909559)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (10969782..10980022)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 15, member 3 Neighboring gene transmembrane protein 132A Neighboring gene transmembrane protein 109 Neighboring gene zona pellucida glycoprotein 1 Neighboring gene prostaglandin D2 receptor 2 Neighboring gene coiled-coil domain containing 86

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular protein localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
 
involved_in generation of catalytic spliceosome for first transesterification step IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within inner cell mass cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of astrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in spliceosomal complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in spliceosomal tri-snRNP complex assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of DNA replication factor A complex ISO
Inferred from Sequence Orthology
more info
 
part_of Prp19 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Prp19 complex ISO
Inferred from Sequence Orthology
more info
 
part_of U2-type catalytic step 1 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of U2-type catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 
NOT part_of spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
pre-mRNA-processing factor 19
Names
PRP19/PSO4 homolog
PRP19/PSO4 pre-mRNA processing factor 19 homolog
RING-type E3 ubiquitin transferase PRP19
nuclear matrix protein 200
nuclear matrix protein SNEV
prp19 beta
senescence evasion factor
NP_001240772.1
NP_001240773.1
NP_598890.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253843.1NP_001240772.1  pre-mRNA-processing factor 19 isoform 1

    See identical proteins and their annotated locations for NP_001240772.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC132402, AK047693
    Consensus CDS
    CCDS57135.1
    UniProtKB/Swiss-Prot
    Q99KP6
    Related
    ENSMUSP00000136858.3, ENSMUST00000179297.3
    Conserved Domains (4) summary
    cd00200
    Location:242522
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:243281
    7WD40; WD40 repeat [structural motif]
    cd16656
    Location:456
    RING-Ubox_PRP19; U-box domain, a modified RING finger, found in pre-mRNA-processing factor 19 (Prp19) and similar proteins
    pfam08606
    Location:69152
    Prp19; Prp19/Pso4-like
  2. NM_001253844.1NP_001240773.1  pre-mRNA-processing factor 19 isoform 3

    See identical proteins and their annotated locations for NP_001240773.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC132402, AK076998
    UniProtKB/Swiss-Prot
    Q99KP6
    Conserved Domains (3) summary
    cd00200
    Location:138418
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:139177
    7WD40; WD40 repeat [structural motif]
    pfam08606
    Location:148
    Prp19; Prp19/Pso4-like
  3. NM_134129.4NP_598890.1  pre-mRNA-processing factor 19 isoform 2

    See identical proteins and their annotated locations for NP_598890.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC132402, AK164681
    Consensus CDS
    CCDS79687.1
    UniProtKB/Swiss-Prot
    Q99KP6
    Related
    ENSMUSP00000025642.9, ENSMUST00000025642.14
    Conserved Domains (4) summary
    cd00200
    Location:223503
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:224262
    7WD40; WD40 repeat [structural motif]
    cd16656
    Location:456
    RING-Ubox_PRP19; U-box domain, a modified RING finger, found in pre-mRNA-processing factor 19 (Prp19) and similar proteins
    pfam08606
    Location:69133
    Prp19; Prp19/Pso4-like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    10872595..10886923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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