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F2 coagulation factor II, thrombin [ Bos taurus (cattle) ]

Gene ID: 280685, updated on 18-Apr-2019

Summary

Official Symbol
F2provided by VGNC
Official Full Name
coagulation factor II, thrombinprovided by VGNC
Primary source
VGNC:VGNC:28682
See related
BGD:BT12387; Ensembl:ENSBTAG00000007148
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs

Genomic context

Location:
chromosome: 15
Exon count:
15
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 15 NC_037342.1 (76656431..76671235)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 15 AC_000172.1 (77530141..77544935)

Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 1 Neighboring gene zinc finger protein 408 Neighboring gene cytoskeleton associated protein 5 Neighboring gene small nucleolar RNA SNORD67 Neighboring gene microRNA mir-2319a Neighboring gene microRNA mir-2319b

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enzyme activator activity IEA
Inferred from Electronic Annotation
more info
 
fibrinogen binding IPI
Inferred from Physical Interaction
more info
PubMed 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
lipopolysaccharide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
thrombospondin receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acute-phase response IEA
Inferred from Electronic Annotation
more info
 
antimicrobial humoral immune response mediated by antimicrobial peptide IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cytolysis by host of symbiont cells IEA
Inferred from Electronic Annotation
more info
 
fibrinolysis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of astrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of proteolysis IEA
Inferred from Electronic Annotation
more info
 
neutrophil mediated killing of gram-negative bacterium IEA
Inferred from Electronic Annotation
more info
 
platelet activation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood coagulation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of collagen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of lipid kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 
protein polymerization IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
prothrombin
Names
thrombin
NP_776302.1
XP_005216458.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173877.1NP_776302.1  prothrombin precursor

    See identical proteins and their annotated locations for NP_776302.1

    Status: PROVISIONAL

    Source sequence(s)
    J00041
    UniProtKB/Swiss-Prot
    P00735
    Related
    ENSBTAP00000009406.5, ENSBTAT00000009406.5
    Conserved Domains (6) summary
    smart00020
    Location:366616
    Tryp_SPc; Trypsin-like serine protease
    smart00069
    Location:2589
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    smart00130
    Location:212294
    KR; Kringle domain
    cd00108
    Location:106187
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00190
    Location:367619
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09396
    Location:319366
    Thrombin_light; Thrombin light chain

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037342.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    76656431..76671235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005216401.4XP_005216458.2  prothrombin isoform X1

    Conserved Domains (5) summary
    smart00069
    Location:2589
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    smart00130
    Location:212294
    KR; Kringle domain
    cd00108
    Location:106187
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00190
    Location:367625
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09396
    Location:320366
    Thrombin_light; Thrombin light chain
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