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CPE carboxypeptidase E [ Bos taurus (cattle) ]

Gene ID: 280753, updated on 9-Mar-2023

Summary

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Official Symbol
CPEprovided by VGNC
Official Full Name
carboxypeptidase Eprovided by VGNC
Primary source
VGNC:VGNC:27648
See related
BGD:BT12828; Ensembl:ENSBTAG00000016514
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
CPH
Orthologs
human mouse all
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Genomic context

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See CPE in Genome Data Viewer
Location:
chromosome: 17
Exon count:
9
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 17 NC_037344.1 (573369..721446)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 17 AC_000174.1 (546402..697925)

Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene kelch like family member 2 Neighboring gene methylsterol monooxygenase 1 Neighboring gene zinc finger FYVE domain-containing protein 1-like Neighboring gene uncharacterized LOC101903170

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and sequence analysis of cDNA for bovine carboxypeptidase E. Fricker LD, et al. Nature, 1986 Oct 2-8. PMID 3020433
  2. Identification and characterization of glycoproteins after extraction of bovine chromaffin-granule membranes with lithium di-iodosalicylate. Purification of glycoprotein II from the soluble fraction. Christie DL, et al. Biochem J, 1990 Aug 15. PMID 2396993, Free PMC Article
  3. Forms of selenium in vitamin-mineral mixes differentially affect the expression of genes responsible for prolactin, ACTH, and α-MSH synthesis and mitochondrial dysfunction in pituitaries of steers grazing endophyte-infected tall fescue. Li Q, et al. J Anim Sci, 2019 Feb 1. PMID 30476104, Free PMC Article
  4. A second generation radiation hybrid map to aid the assembly of the bovine genome sequence. Jann OC, et al. BMC Genomics, 2006 Nov 6. PMID 17087818, Free PMC Article
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular function activator activity IEA
Inferred from Electronic Annotation
more info
  
enables neurexin family protein binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cardiac left ventricle morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in insulin processing IEA
Inferred from Electronic Annotation
more info
  
involved_in peptide hormone secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to secretory granule IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in secretory granule membrane IEA
Inferred from Electronic Annotation
more info
  
located_in transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carboxypeptidase E
Names
carboxypeptidase H
enkephalin convertase
prohormone-processing carboxypeptidase
NP_776328.2
XP_010811943.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173903.4 → NP_776328.2  carboxypeptidase E precursor

    See identical proteins and their annotated locations for NP_776328.2

    Status: VALIDATED

    Source sequence(s)
    DV829793, DV831465, EE221590, EE241409, EH201801, EW682509, NKLS02000017
    UniProtKB/Swiss-Prot
    P04836, Q6YI55
    UniProtKB/TrEMBL
    A0A4W2H158, A0A8B9Y2I6
    Related
    ENSBTAP00000021955.5, ENSBTAT00000021955.6
    Conserved Domains (2) summary
    cd11308
    Location:374 → 448
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cl11393
    Location:48 → 370
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037344.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    573369..721446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010813641.2 → XP_010811943.1  carboxypeptidase E isoform X1

    Conserved Domains (1) summary
    cl11393
    Location:48 → 370
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04836.2 GenPept UniProtKB/Swiss-Prot:P04836

Gene LinkOut

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