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HCK HCK proto-oncogene, Src family tyrosine kinase [ Bos taurus (cattle) ]

Gene ID: 280814, updated on 11-Apr-2024

Summary

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Official Symbol
HCKprovided by VGNC
Official Full Name
HCK proto-oncogene, Src family tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:29774
See related
BGD:BT22241; Ensembl:ENSBTAG00000007932
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (61563147..61608503)

Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene XK related 7 Neighboring gene craniofacial development protein 2-like Neighboring gene CCM2 like scaffold protein Neighboring gene transmembrane 9 superfamily member 4 Neighboring gene PLAG1 like zinc finger 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of hck-tr, a truncated form of the src-related tyrosine kinase hck, in bovine spermatozoa and testis. Bordeleau LJ, et al. Mol Reprod Dev, 2008 May. PMID 17926339
  2. Bull testicular haploid germ cells express a messenger encoding for a truncated form of the protein tyrosine kinase HCK. Lalancette C, et al. Mol Reprod Dev, 2006 Apr. PMID 16432821
  3. Comparative mapping of bovine chromosome 13 by fluorescence in situ hybridization. Schläpfer J, et al. Anim Genet, 1998 Aug. PMID 9745664
  4. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the presence of mRNAs encoding for hck and hck-tr in testicular germ cells; hck-tr being translated during spermatogenesis and expressed on mature ejaculated bull spermatozoa.
    Title: Expression of hck-tr, a truncated form of the src-related tyrosine kinase hck, in bovine spermatozoa and testis.
  2. A truncated, mRNA-encoded src-related tyrosine kinase HCK could function as an adaptor protein or as a competitive inhibitor in spermiogenesis or mature sperm functions.
    Title: Bull testicular haploid germ cells express a messenger encoding for a truncated form of the protein tyrosine kinase HCK.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase HCK
Names
hemopoietic cell kinase
NP_001032218.2
NP_001103664.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037141.3 → NP_001032218.2  tyrosine-protein kinase HCK isoform 2

    See identical proteins and their annotated locations for NP_001032218.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) appears to be restricted to the testis. It is missing several 5' and 3' exons found in transcript variant 1, resulting in a shorter isoform (2), with different N- and C- termini, compared to isoform 1.
    Source sequence(s)
    NKLS02000013
    UniProtKB/TrEMBL
    F1MTD8, Q38KH2
    Related
    ENSBTAP00000037156.3, ENSBTAT00000037322.4
    Conserved Domains (3) summary
    cd10363
    Location:37 → 140
    SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK
    cl17036
    Location:9 → 34
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:147 → 237
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001110194.1 → NP_001103664.1  tyrosine-protein kinase HCK isoform 1

    See identical proteins and their annotated locations for NP_001103664.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer and more predominant transcript. It initiates translation from an upstream non-AUG (CUG) start codon (resulting in isoform 1), and alternatively from an in-frame, downstream AUG.
    Source sequence(s)
    NKLS02000013
    UniProtKB/TrEMBL
    F1MWN2
    Related
    ENSBTAP00000051020.2, ENSBTAT00000056914.3
    Conserved Domains (4) summary
    cd10363
    Location:138 → 241
    SH2_Src_HCK; Src homology 2 (SH2) domain found in HCK
    pfam07714
    Location:260 → 509
    Pkinase_Tyr; Protein tyrosine kinase
    cl17036
    Location:80 → 135
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:252 → 522
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    61563147..61608503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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