INS insulin [Bos taurus (cattle)] - Gene

Summary

Official Symbol: INSprovided by VGNC
Official Full Name: insulinprovided by VGNC
Primary source: VGNC:VGNC:56268
See related: BGD:BT10074; Ensembl:ENSBTAG00000013003
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 29

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	29	NC_037356.1 (49393375..49394536)

Chromosome 29 - NC_037356.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Docking interactions determine early cleavage events in insulin proteolysis by pepsin: Experiment and simulation.
Title: Docking interactions determine early cleavage events in insulin proteolysis by pepsin: Experiment and simulation.
The Hydration Shell of Monomeric and Dimeric Insulin Studied by Terahertz Time-Domain Spectroscopy.
Title: The Hydration Shell of Monomeric and Dimeric Insulin Studied by Terahertz Time-Domain Spectroscopy.
Top-down analyses of protonated insulin cations of charge states of 4+, 5+, or 6+ were performed by exposing the isolated precursor ions to a beam of helium cations with kinetic energy of more than 6 keV, in a technique termed charge transfer dissociation.
Title: Top-Down Charge Transfer Dissociation (CTD) of Gas-Phase Insulin: Evidence of a One-Step, Two-Electron Oxidation Mechanism.
The structural dynamics of insulin hexamer dissociation were studied by the photoinduced temperature jump technique and monitored by time-resolved X-ray scattering. The process of hexamer dissociation was found to involve several transient intermediates, including an expanded hexamer and an unstable tetramer.
Title: Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering.
Insulin signaling role in skeletal muscle atrophy and autophagy in in transition and postpartum period
Title: Insulin signaling and skeletal muscle atrophy and autophagy in transition dairy cows either overfed energy or fed a controlled energy diet prepartum.
Structural changes consistent with protein partitioning to the membrane interior and adsorption to a gel phase model lipid bilayer were observed under conditions where the native fold of the protein is significantly destabilised.
Title: Interaction of partially denatured insulin with a DSPC floating lipid bilayer.
Differences between human and bovine insulin kinetics under shear
Title: Comparison of Human and Bovine Insulin Amyloidogenesis under Uniform Shear.
increased sensitivity to glucose clearance and skeletal muscle insulin signaling during dietary restriction
Title: Insulin secretion and signaling in response to dietary restriction and subsequent re-alimentation in cattle.
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin-NPY and insulin signaling pathways.
Title: Gene expression profiling of hormonal regulation related to the residual feed intake of Holstein cattle.
Raman spectra of amino acids by Density Functional Theory method have been calculated. Experimental Raman spectra of insulin has been done. The simulated Raman spectrum of insulin is obtained from amino acid spectrum.
Title: Quantum-mechanical DFT calculation supported Raman spectroscopic study of some amino acids in bovine insulin.

Submit: New GeneRIF Correction See all GeneRIFs (37)

General gene information

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Markers

PMC24644P6 (e-PCR)
- UniSTS:265494

Ins1 (e-PCR), detects polymorphism
- UniSTS:265494

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of protein secretion	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: insulin

Names: proinsulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001185126.1 → NP_001172055.1 insulin preproprotein

See identical proteins and their annotated locations for NP_001172055.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

EH379095, EV652245

UniProtKB/Swiss-Prot

P01317

UniProtKB/TrEMBL

A5PJB2

Related

ENSBTAP00000017289.4, ENSBTAT00000017289.5

Conserved Domains (1) summary

cd04367
Location:26 → 105

IlGF_insulin_like; IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and ...
NM_173926.2 → NP_776351.2 insulin preproprotein

See identical proteins and their annotated locations for NP_776351.2

Status: VALIDATED

Description

Transcript Variant: This transcript (1) represents the shorter variant. Variants 1 and 2 encode the same protein.

Source sequence(s)

EV652245

UniProtKB/Swiss-Prot

P01317

UniProtKB/TrEMBL

A5PJB2

Conserved Domains (1) summary

cd04367
Location:26 → 105

IlGF_insulin_like; IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and ...