SCD stearoyl-CoA desaturase [Bos taurus (cattle)] - Gene

Summary

Official Symbol: SCDprovided by VGNC
Official Full Name: stearoyl-CoA desaturaseprovided by VGNC
Primary source: VGNC:VGNC:106916
See related: Ensembl:ENSBTAG00000055207
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: SCD1
Orthologs: human all
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Genomic context

Location:: chromosome: 26

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	26	NC_037353.1 (21263976..21279185)

Chromosome 26 - NC_037353.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LEP and SCD polymorphisms are associated with milk somatic cell count, electrical conductivity and pH values in Holstein cows.
Title: LEP and SCD polymorphisms are associated with milk somatic cell count, electrical conductivity and pH values in Holstein cows.
Bovine Stearoyl-CoA Desaturase 1 Promotes Adipogenesis by Activating the PPARgamma Receptor.
Title: Bovine Stearoyl-CoA Desaturase 1 Promotes Adipogenesis by Activating the PPARγ Receptor.
Expression of SCD1 was downregulated through reduced transcription and abundance of the transcription factor sterol regulatory element-binding protein 1 (SREBP1c).This effect was augmented by local chromatin tightening and DNA methylation at and around the SREBP1c binding site in the SCD1 promoter
Title: Epigenetic mechanisms contribute to decrease stearoyl-CoA desaturase 1 expression in the liver of dairy cows after prolonged feeding of high-concentrate diet.
It plays important roles in growth and lipid metabolisms.
Title: Epistatic effects between pairs of the growth hormone secretagogue receptor 1a, growth hormone, growth hormone receptor, non-SMC condensin I complex, subunit G and stearoyl-CoA desaturase genes on carcass, price-related and fatty acid composition traits in Japanese Black cattle.
E. coli mastitis reduced SCD1 expression in liver and udder.
Title: Stearoyl-CoA desaturase 1 expression is downregulated in liver and udder during E. coli mastitis through enhanced expression of repressive C/EBP factors and reduced expression of the inducer SREBP1A.
Here, the association between DGAT1 K232A, SCD1 A293V, and LEPR T945M markers with milk fat composition in southern Chile was evaluated. The most frequent variants for DGAT1, SCD1, and LEPR polymorphisms were GC/GC, C, and C, respectively. The SCD1 CC genotype was associated with a low cholesterolemic FA content, a high ratio of linolenic acid to cholesterolemic FA, and lower conjugated-linolenic acid and PUFA content.
Title: Milk fatty acid profile is modulated by DGAT1 and SCD1 genotypes in dairy cattle on pasture and strategic supplementation.
significant effects of the SCD gene on milk medium- and long-chain unsaturated fatty acids, especially for C14:1 and C14 index in dairy cattle
Title: A post-GWAS confirming the SCD gene associated with milk medium- and long-chain unsaturated fatty acids in Chinese Holstein population.
Studied the responsiveness of bovine SCD1 promoter to serum, insulin, oleic acid, and NFY transcription factor in BME-UV1 cells.
Title: Regulation of Stearoyl Coenzyme A Desaturase 1 Gene Promoter in Bovine Mammary Cells.
The results suggest that a mutation of SCD1, but not LEPR or ABCG2, might be useful as a DNA marker to decrease reproductive problems and improve production traits in Iranian Holstein dairy cows.
Title: Effect of LEPR, ABCG2 and SCD1 gene polymorphisms on reproductive traits in the Iranian Holstein cattle.
Suppression of CPT1B and induction of SCD and CEBPB by supplemental arginine promotes increased adiposity in Angus steers.
Title: Abomasal infusion of arginine stimulates SCD and C/EBPß gene expression, and decreases CPT1ß gene expression in bovine adipose tissue independent of conjugated linoleic acid.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables iron ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables palmitoyl-CoA 9-desaturase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables stearoyl-CoA 9-desaturase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in response to fatty acid	IEA Inferred from Electronic Annotation more info	PubMed
involved_in unsaturated fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: stearoyl-CoA desaturase

Names: acyl-CoA desaturase; delta(9)-desaturase; fatty acid desaturase; stearoyl-CoA desaturase (delta-9-desaturase); stearoyl-coenzyme A desaturase

NP_776384.3

EC 1.14.19.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173959.4 → NP_776384.3 stearoyl-CoA desaturase

See identical proteins and their annotated locations for NP_776384.3

Status: PROVISIONAL

Source sequence(s)

AY241933

UniProtKB/Swiss-Prot

Q861R6, Q8SQ76, Q9TT94

UniProtKB/TrEMBL

Q867D1

Related

ENSBTAP00000070213.1, ENSBTAT00000078682.2

Conserved Domains (1) summary

cd03505
Location:97 → 337

Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...