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M6PR mannose-6-phosphate receptor, cation dependent [ Bos taurus (cattle) ]

Gene ID: 281291, updated on 5-Mar-2024

Summary

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Official Symbol
M6PRprovided by VGNC
Official Full Name
mannose-6-phosphate receptor, cation dependentprovided by VGNC
Primary source
VGNC:VGNC:31125
See related
BGD:BT16173; Ensembl:ENSBTAG00000018207
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
CDMPR; CD-MPR
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (100984454..100997335)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene alpha-2-macroglobulin Neighboring gene killer cell lectin like receptor G1 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene polyhomeotic homolog 1 Neighboring gene alpha-2-macroglobulin like 1 Neighboring gene microRNA mir-2284r

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A determinant in the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor prevents trafficking to lysosomes. Rohrer J, et al. J Cell Biol, 1995 Sep. PMID 7559753, Free PMC Article
  2. 46 kd mannose 6-phosphate receptor: cloning, expression, and homology to the 215 kd mannose 6-phosphate receptor. Dahms NM, et al. Cell, 1987 Jul 17. PMID 2954652
  3. The cation-dependent mannose 6-phosphate receptor. Structural requirements for mannose 6-phosphate binding and oligomerization. Dahms NM, et al. J Biol Chem, 1989 Jul 5. PMID 2544594
  4. Rotaviruses reach late endosomes and require the cation-dependent mannose-6-phosphate receptor and the activity of cathepsin proteases to enter the cell. Díaz-Salinas MA, et al. J Virol, 2014 Apr. PMID 24501398, Free PMC Article
  5. Molecular basis of lysosomal enzyme recognition: three-dimensional structure of the cation-dependent mannose 6-phosphate receptor. Roberts DL, et al. Cell, 1998 May 15. PMID 9604938

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rotaviruses reach late endosomes and require M6PR and cathepsin proteases to enter the cell.
    Title: Rotaviruses reach late endosomes and require the cation-dependent mannose-6-phosphate receptor and the activity of cathepsin proteases to enter the cell.
  2. Expression and binding properties of mannose-6-phosphate receptors CD-MPR and CI-MPR differ during perinatal development in rat liver.
    Title: Expression and binding properties of the two mannose-6-phosphate receptors differ during perinatal development in rat liver.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC140730

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein targeting to lysosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cation-dependent mannose-6-phosphate receptor
Names
46 kDa mannose 6-phosphate receptor
CD Man-6-P receptor
MPR 46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175779.3 → NP_786973.1  cation-dependent mannose-6-phosphate receptor precursor

    See identical proteins and their annotated locations for NP_786973.1

    Status: PROVISIONAL

    Source sequence(s)
    BC120081
    UniProtKB/Swiss-Prot
    A1L5A0, P11456, Q0VCN7
    Related
    ENSBTAP00000088610.1, ENSBTAT00000091971.1
    Conserved Domains (1) summary
    pfam02157
    Location:2 → 279
    Man-6-P_recep; Mannose-6-phosphate receptor

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    100984454..100997335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015471262.3 → XP_015326748.1  cation-dependent mannose-6-phosphate receptor isoform X1

    Related
    ENSBTAP00000024233.3, ENSBTAT00000024233.5
    Conserved Domains (1) summary
    pfam02157
    Location:1 → 278
    Man-6-P_recep; Mannose-6-phosphate receptor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11456.1 GenPept UniProtKB/Swiss-Prot:P11456

Gene LinkOut

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Research Materials
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