Format

Send to:

Choose Destination

MSR1 macrophage scavenger receptor 1 [ Bos taurus (cattle) ]

Gene ID: 281311, updated on 6-May-2021

Summary

Official Symbol
MSR1provided by VGNC
Official Full Name
macrophage scavenger receptor 1provided by VGNC
Primary source
VGNC:VGNC:31704
See related
BGD:BT16011; Ensembl:ENSBTAG00000002885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MSR1 in Genome Data Viewer
Location:
chromosome: 27
Exon count:
12
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 27 NC_037354.1 (20909832..20990599)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 27 AC_000184.1 (19976199..20056663)

Chromosome 27 - NC_037354.1Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 20 Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene tumor suppressor candidate 3 Neighboring gene putative methyltransferase NSUN5C

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables Hsp90 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables amyloid-beta binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables low-density lipoprotein particle binding IEA
Inferred from Electronic Annotation
more info
 
enables scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in amyloid-beta clearance IEA
Inferred from Electronic Annotation
more info
 
involved_in cholesterol transport IEA
Inferred from Electronic Annotation
more info
 
involved_in lipoprotein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in phagocytosis, engulfment IEA
Inferred from Electronic Annotation
more info
 
involved_in plasma lipoprotein particle clearance IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cholesterol storage IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of macrophage derived foam cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein homotrimerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
part_of low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
macrophage scavenger receptor types I and II
Names
macrophage acetylated LDL receptor I and II

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113240.1NP_001106711.1  macrophage scavenger receptor types I and II isoform 1

    See identical proteins and their annotated locations for NP_001106711.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and protein isoform (1).
    Source sequence(s)
    AJ677598, AM037916, DY085614, X51689
    UniProtKB/Swiss-Prot
    P21758
    Related
    ENSBTAP00000003751.3, ENSBTAT00000003751.4
    Conserved Domains (4) summary
    pfam01391
    Location:279333
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:352452
    SR; Scavenger receptor Cys-rich
    pfam03523
    Location:120168
    Macscav_rec; Macrophage scavenger receptor
    cl25732
    Location:111253
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_174113.2NP_776538.1  macrophage scavenger receptor types I and II isoform 2

    See identical proteins and their annotated locations for NP_776538.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a distinct terminal exon resulting in a shorter protein isoform (2).
    Source sequence(s)
    AM018111, DY085614, X51689, X54183
    UniProtKB/Swiss-Prot
    P21758
    Related
    ENSBTAP00000003755.5, ENSBTAT00000003755.6
    Conserved Domains (3) summary
    pfam01391
    Location:279333
    Collagen; Collagen triple helix repeat (20 copies)
    pfam03523
    Location:120168
    Macscav_rec; Macrophage scavenger receptor
    cl25732
    Location:111253
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037354.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    20909832..20990599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005226029.4XP_005226086.1  macrophage scavenger receptor types I and II isoform X2

    Conserved Domains (2) summary
    pfam01391
    Location:279333
    Collagen; Collagen triple helix repeat (20 copies)
    pfam03523
    Location:120168
    Macscav_rec; Macrophage scavenger receptor
  2. XM_024986175.1XP_024841943.1  macrophage scavenger receptor types I and II isoform X1

    Conserved Domains (4) summary
    pfam01391
    Location:279333
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:352452
    SR; Scavenger receptor Cys-rich
    pfam03523
    Location:120168
    Macscav_rec; Macrophage scavenger receptor
    cl25732
    Location:111253
    SMC_N; RecF/RecN/SMC N terminal domain
Support Center