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SOD1 superoxide dismutase 1 [ Bos taurus (cattle) ]

Gene ID: 281495, updated on 14-Jan-2019

Summary

Gene symbol
SOD1
Gene description
superoxide dismutase 1
See related
BGD:BT12476; Ensembl:ENSBTAG00000018854
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
SOD1L1
Orthologs

Genomic context

See SOD1 in Genome Data Viewer
Location:
1q12-q14
Exon count:
5
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 1 NC_037328.1 (3824612..3833280, complement)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 1 AC_000158.1 (3113948..3122613, complement)

Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112447138 Neighboring gene hormonally up-regulated Neu-associated kinase Neighboring gene SR-related CTD associated factor 4 Neighboring gene T cell lymphoma invasion and metastasis 1 Neighboring gene microRNA 2284i Neighboring gene microRNA 2284x

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

  • Homologs of the SOD1 gene: The SOD1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs from Annotation Pipeline: 244 organisms have orthologs with human gene SOD1
  • Orthologs

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chaperone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
copper ion binding IDA
Inferred from Direct Assay
more info
PubMed 
copper ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase 2B binding ISS
Inferred from Sequence or Structural Similarity
more info
 
superoxide dismutase activity IDA
Inferred from Direct Assay
more info
PubMed 
superoxide dismutase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
activation of MAPK activity ISS
Inferred from Sequence or Structural Similarity
more info
 
auditory receptor cell stereocilium organization ISS
Inferred from Sequence or Structural Similarity
more info
 
cell aging ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular iron ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
embryo implantation ISS
Inferred from Sequence or Structural Similarity
more info
 
glutathione metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
heart contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
hydrogen peroxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
interspecies interaction between organisms IDA
Inferred from Direct Assay
more info
PubMed 
locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
muscle cell cellular homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
myeloid cell homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cholesterol biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
neurofilament cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
ovarian follicle development ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
peripheral nervous system myelin maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of catalytic activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of catalytic activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of nitric-oxide synthase biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
protein polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
reactive oxygen species metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitochondrial membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitochondrial membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of multicellular organism growth ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
relaxation of vascular smooth muscle ISS
Inferred from Sequence or Structural Similarity
more info
 
removal of superoxide radicals IDA
Inferred from Direct Assay
more info
PubMed 
removal of superoxide radicals ISS
Inferred from Sequence or Structural Similarity
more info
 
response to axon injury ISS
Inferred from Sequence or Structural Similarity
more info
 
response to drug ISS
Inferred from Sequence or Structural Similarity
more info
 
response to ethanol ISS
Inferred from Sequence or Structural Similarity
more info
 
response to heat ISS
Inferred from Sequence or Structural Similarity
more info
 
response to hydrogen peroxide ISS
Inferred from Sequence or Structural Similarity
more info
 
response to organic substance ISS
Inferred from Sequence or Structural Similarity
more info
 
response to superoxide ISS
Inferred from Sequence or Structural Similarity
more info
 
retina homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
sensory perception of sound ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
superoxide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
transmission of nerve impulse ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
superoxide dismutase [Cu-Zn]
Names
Cu-Zn superoxide dismutase
superoxide dismutase 1, soluble
NP_777040.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174615.2NP_777040.1  superoxide dismutase [Cu-Zn]

    See identical proteins and their annotated locations for NP_777040.1

    Status: PROVISIONAL

    Source sequence(s)
    M81129
    UniProtKB/Swiss-Prot
    P00442
    Related
    ENSBTAP00000032384.3, ENSBTAT00000032452.4
    Conserved Domains (1) summary
    cd00305
    Location:3145
    Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037328.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    3824612..3833280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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