SPP1 secreted phosphoprotein 1 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: SPP1provided by VGNC
Official Full Name: secreted phosphoprotein 1provided by VGNC
Primary source: VGNC:VGNC:35232
See related: BGD:BT11993; Ensembl:ENSBTAG00000005260
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: OPN; OST
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	6	NC_037333.1 (36693204..36700208, complement)

Chromosome 6 - NC_037333.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study first addressed in detail the LF/fOPN interaction and proposed a LF:fOPN 4/1 maximal stoichiometry.
Title: Reactivity of U-associated osteopontin with lactoferrin: a one-to-many complex.
This implies that a majority of the acidic residues within OPN must be engaged in calcium interaction under physiological conditions.
Title: Osteopontin binds multiple calcium ions with high affinity and independently of phosphorylation status.
Genetic variations in the SPP1 promoter affect gene expression and the level of osteopontin secretion into bovine milk.
Title: Genetic variations in the SPP1 promoter affect gene expression and the level of osteopontin secretion into bovine milk.
Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.
Title: Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.
osteopontin (OPN) can serve as a process-directing agent for the intrafibrillar mineralization of collagen.
Title: Multifunctional role of osteopontin in directing intrafibrillar mineralization of collagen and activation of osteoclasts.
Results suggest a mechanism of the interaction of UO2(2+) with bone metabolism and a new role for osteopontin (OPN) as a metal transporter.
Title: Characterization of UO2(2+) binding to osteopontin, a highly phosphorylated protein: insights into potential mechanisms of uranyl accumulation in bones.
Upon induction of luteolysis, SPP1 serves as a signaling molecule to recruit or activate immune cells to facilitate luteal regression and tissue degradation.
Title: Expression and regulation of secreted phosphoprotein 1 in the bovine corpus luteum and effects on T lymphocyte chemotaxis.
OPN strongly reduces the amount of biofilm formed in a well-defined laboratory model of acidogenic dental biofilm.
Title: Osteopontin reduces biofilm formation in a multi-species model of dental biofilm.
This study demonstrates that adhesion of isolated neonatal rat osteoclasts in vitro was augmented on bovine milk osteopontin (bmOPN) with post-translational modifications (PTMs) compared to human Escherichia-coli-derived recombinant OPN without PTMs.
Title: Osteoclast migration on phosphorylated osteopontin is regulated by endogenous tartrate-resistant acid phosphatase.
the present study is the first to demonstrate functionally that SPP1 directly binds specific integrins to promote trophectoderm cell migration and attachment to luminal epithelium that may be critical to conceptus elongation and implantation.
Title: Secreted phosphoprotein 1 (SPP1, osteopontin) binds to integrin alpha v beta 6 on porcine trophectoderm cells and integrin alpha v beta 3 on uterine luminal epithelial cells, and promotes trophectoderm cell adhesion and migration.

Submit: New GeneRIF Correction See all GeneRIFs (22)

General gene information

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Markers

SPP1 (e-PCR)
- UniSTS:279138

RW7 (e-PCR)
- UniSTS:241571

SPP1 (e-PCR)
- UniSTS:519124

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables extracellular matrix binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in ossification	IEA Inferred from Electronic Annotation more info	PubMed
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of bone resorption	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: osteopontin

Names: SPP-1; bone sialoprotein 1; bone sialoprotein I; early T-lymphocyte activation 1; osteopontin-K; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.