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FGFR3 fibroblast growth factor receptor 3 [ Bos taurus (cattle) ]

Gene ID: 281769, updated on 3-Apr-2024

Summary

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Official Symbol
FGFR3provided by VGNC
Official Full Name
fibroblast growth factor receptor 3provided by VGNC
Primary source
VGNC:VGNC:50180
See related
Ensembl:ENSBTAG00000007164
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (116766308..116781167, complement)

Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA 23 Neighboring gene nuclear receptor binding SET domain protein 2 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1 Neighboring gene transforming acidic coiled-coil containing protein 3 Neighboring gene transmembrane protein 129, E3 ubiquitin ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. De novo stop-lost germline mutation in FGFR3 causes severe chondrodysplasia in the progeny of a Holstein bull. Häfliger IM, et al. Anim Genet, 2020 Jun. PMID 32239744
  2. Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3. Degnin CR, et al. Mol Biol Cell, 2011 Oct. PMID 21865593, Free PMC Article
  3. The bovine fibroblast growth factor receptor 3 (FGFR3) gene is not the locus responsible for bovine chondrodysplastic dwarfism in Japanese brown cattle. Takami M, et al. Anim Genet, 2002 Oct. PMID 12354143
  4. Somatic cell nuclear transfer is associated with altered expression of angiogenic factor systems in bovine placentomes at term. Campos DB, et al. Genet Mol Res, 2010 Feb 23. PMID 20198587
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. De novo stop-lost germline mutation in FGFR3 causes severe chondrodysplasia in the progeny of a Holstein bull.
    Title: De novo stop-lost germline mutation in FGFR3 causes severe chondrodysplasia in the progeny of a Holstein bull.
  2. The ectodomain of FGFR3 is proteolytically cleaved in response to ligand-induced receptor activation by FGF1, but unlike most regulated intramembrane proteolysis target proteins, it requires endocytosis and does not involve a metalloproteinase.
    Title: Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3.
  3. Alterations in the expression of VEGF-A and bFGF systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
    Title: Somatic cell nuclear transfer is associated with altered expression of angiogenic factor systems in bovine placentomes at term.
  4. chondrodysplastic dwarfism in Japanese brown cattle is not caused by mutation in the FGFR3 gene
    Title: The bovine fibroblast growth factor receptor 3 (FGFR3) gene is not the locus responsible for bovine chondrodysplastic dwarfism in Japanese brown cattle.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fibroblast growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fibroblast growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
fibroblast growth factor receptor 3
Names
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)
NP_776743.1
XP_024848758.1
XP_024848759.1
XP_024848761.1
XP_024848762.1
XP_024848764.1
XP_024848765.1
XP_024848767.1
XP_059743299.1
XP_059743300.1
XP_059743301.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174318.3 → NP_776743.1  fibroblast growth factor receptor 3 precursor

    See identical proteins and their annotated locations for NP_776743.1

    Status: VALIDATED

    Source sequence(s)
    AB059430
    UniProtKB/TrEMBL
    F6PVB0, Q95M13
    Related
    ENSBTAP00000064396.2, ENSBTAT00000075084.2
    Conserved Domains (4) summary
    cd05857
    Location:157 → 241
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:264 → 353
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:52 → 109
    IGc2; Immunoglobulin C-2 Type
    cl21453
    Location:455 → 788
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    116766308..116781167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024992997.2 → XP_024848765.1  fibroblast growth factor receptor 3 isoform X7

    UniProtKB/TrEMBL
    F6PVB0
    Conserved Domains (4) summary
    cd05857
    Location:157 → 241
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:264 → 353
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:52 → 109
    IGc2; Immunoglobulin C-2 Type
    cl21453
    Location:456 → 789
    PKc_like; Protein Kinases, catalytic domain

  2. XM_024992996.2 → XP_024848764.1  fibroblast growth factor receptor 3 isoform X6

    UniProtKB/TrEMBL
    A0A3Q1MPT9, F6PVB0
    Related
    ENSBTAP00000073540.2, ENSBTAT00000086336.2
    Conserved Domains (4) summary
    cd05857
    Location:157 → 241
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:52 → 109
    IGc2; Immunoglobulin C-2 Type
    cd04974
    Location:264 → 351
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cl21453
    Location:457 → 790
    PKc_like; Protein Kinases, catalytic domain

  3. XM_059887316.1 → XP_059743299.1  fibroblast growth factor receptor 3 isoform X5

  4. XM_024992999.2 → XP_024848767.1  fibroblast growth factor receptor 3 isoform X8

    UniProtKB/TrEMBL
    F6PVB0, Q95M13
    Conserved Domains (4) summary
    cd05857
    Location:157 → 241
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:264 → 353
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:52 → 109
    IGc2; Immunoglobulin C-2 Type
    cl21453
    Location:455 → 788
    PKc_like; Protein Kinases, catalytic domain

  5. XM_059887318.1 → XP_059743301.1  fibroblast growth factor receptor 3 isoform X10

  6. XM_059887317.1 → XP_059743300.1  fibroblast growth factor receptor 3 isoform X9

  7. XM_024992990.2 → XP_024848758.1  fibroblast growth factor receptor 3 isoform X1

    Conserved Domains (4) summary
    cd05857
    Location:167 → 251
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:62 → 119
    IGc2; Immunoglobulin C-2 Type
    cd04974
    Location:274 → 361
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cl21453
    Location:468 → 801
    PKc_like; Protein Kinases, catalytic domain

  8. XM_024992993.2 → XP_024848761.1  fibroblast growth factor receptor 3 isoform X3

    UniProtKB/TrEMBL
    F6PVB0
    Conserved Domains (4) summary
    cd05857
    Location:167 → 251
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:274 → 363
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:62 → 119
    IGc2; Immunoglobulin C-2 Type
    cl21453
    Location:466 → 799
    PKc_like; Protein Kinases, catalytic domain

  9. XM_024992991.2 → XP_024848759.1  fibroblast growth factor receptor 3 isoform X2

    Conserved Domains (4) summary
    cd05857
    Location:167 → 251
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00408
    Location:62 → 119
    IGc2; Immunoglobulin C-2 Type
    cd04974
    Location:274 → 361
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cl21453
    Location:467 → 800
    PKc_like; Protein Kinases, catalytic domain

  10. XM_024992994.2 → XP_024848762.1  fibroblast growth factor receptor 3 isoform X4

    UniProtKB/TrEMBL
    F6PVB0
    Related
    ENSBTAP00000076064.1, ENSBTAT00000129080.1
    Conserved Domains (4) summary
    cd05857
    Location:167 → 251
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:274 → 363
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:62 → 119
    IGc2; Immunoglobulin C-2 Type
    cl21453
    Location:465 → 798
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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