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GNAT1 G protein subunit alpha transducin 1 [ Bos taurus (cattle) ]

Gene ID: 281794, updated on 5-Mar-2024

Summary

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Official Symbol
GNAT1provided by VGNC
Official Full Name
G protein subunit alpha transducin 1provided by VGNC
Primary source
VGNC:VGNC:29454
See related
BGD:BT14171; Ensembl:ENSBTAG00000018020
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
HG1F
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (50152601..50161293, complement)

Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene solute carrier family 38 member 3 Neighboring gene semaphorin 3F Neighboring gene RNA binding motif protein 5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional heterogeneity of transducin alpha subunits. Neubert TA, et al. FEBS Lett, 1998 Feb 6. PMID 9498812
  2. The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S. Noel JP, et al. Nature, 1993 Dec 16. PMID 8259210
  3. GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4. Sondek J, et al. Nature, 1994 Nov 17. PMID 7969474
  4. [Isolation and characteristics of cyanogen bromide peptides of transducin alpha and beta subunits]. Lipkin VM, et al. Bioorg Khim, 1985 Nov. PMID 3867352
  5. GTPase of bovine rod outer segments: the amino acid sequence of the alpha subunit as derived from the cDNA sequence. Yatsunami K, et al. Proc Natl Acad Sci U S A, 1985 Jul. PMID 2989813, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6.
    Title: Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6.
  2. Data suggest that a hetero-multimer complex forms between light-activated rhodopsin and light-activated heterotrimeric transducin (T-alpha-1, Gnb1, Gngt1); the stoichiometry is 1:1 rhodopsin:transducin. The complex appears to form on native rod outer segment membranes upon light activation.
    Title: Isolation and structure-function characterization of a signaling-active rhodopsin-G protein complex.
  3. These results indicated that efficient Gt activation by rhodopsin, resulting from an optimized active state of rhodopsin, is one of the causes of the high amplification efficiency of rods.
    Title: Rod visual pigment optimizes active state to achieve efficient G protein activation as compared with cone visual pigments.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of heterotrimeric G-protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
guanine nucleotide-binding protein G(t) subunit alpha-1
Names
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
heterotrimeric guanine nucleotide-binding protein 1F
transducin alpha-1 chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181022.2 → NP_851365.1  guanine nucleotide-binding protein G(t) subunit alpha-1

    See identical proteins and their annotated locations for NP_851365.1

    Status: PROVISIONAL

    Source sequence(s)
    X02440
    UniProtKB/Swiss-Prot
    P04695
    Related
    ENSBTAP00000023990.5, ENSBTAT00000023990.6
    Conserved Domains (1) summary
    cd00066
    Location:30 → 344
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    50152601..50161293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024982388.2 → XP_024838156.1  guanine nucleotide-binding protein G(t) subunit alpha-1 isoform X1

    Related
    ENSBTAP00000077592.1, ENSBTAT00000119899.1
    Conserved Domains (1) summary
    cd00066
    Location:51 → 365
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04695.3 GenPept UniProtKB/Swiss-Prot:P04695

Gene LinkOut

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Research Materials
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