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IFNB1 interferon, beta 1, fibroblast [ Bos taurus (cattle) ]

Gene ID: 281845, updated on 22-Oct-2023

Summary

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Gene symbol
IFNB1
Gene description
interferon, beta 1, fibroblast
See related
BGD:BT10583
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
IFNb
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Genomic context

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Location:
chromosome: 8
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (23263785..23264421)

Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132345933 Neighboring gene interferon alpha-2-like Neighboring gene interferon omega-1-like Neighboring gene interferon alpha-2 Neighboring gene interferon beta-2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Type 2 BVDV N(pro) suppresses IFN-1 pathway signaling in bovine cells and augments BRSV replication. Alkheraif AA, et al. Virology, 2017 Jul. PMID 28432927
  2. Infection of cultured bovine cells with bovine herpesvirus 1 (BHV-1) or Sendai virus induces different beta interferon subtypes. da Silva LF, et al. Virus Res, 2011 Apr. PMID 21316405, Free PMC Article
  3. Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells. Singh N, et al. J Interferon Cytokine Res, 2016 Jan. PMID 26418342, Free PMC Article
  4. ICP27 protein encoded by bovine herpesvirus type 1 (bICP27) interferes with promoter activity of the bovine genes encoding beta interferon 1 (IFN-β1) and IFN-β3. da Silva LF, et al. Virus Res, 2012 Oct. PMID 22902481, Free PMC Article
  5. Cytoplasmic localized infected cell protein 0 (bICP0) encoded by bovine herpesvirus 1 inhibits β interferon promoter activity and reduces IRF3 (interferon response factor 3) protein levels. da Silva LF, et al. Virus Res, 2011 Sep. PMID 21689696, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BVDV2-E significantly increased IFN-beta activity compared to BVDV2-wt.
    Title: Type 2 BVDV N(pro) suppresses IFN-1 pathway signaling in bovine cells and augments BRSV replication.
  2. The data confirm the involvement of EHMT2 in the epigenetic regulation of IFN-b and demonstrate the activation of a general antiviral state after EHMT2 inhibition.
    Title: Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells.
  3. The authors provide evidence that ICP27 protein encoded by bovine herpesvirus type 1, a viral early protein that shuttles between the nucleus and cytoplasm inhibits transcriptional activity of two bovine IFN-beta gene promoters (IFN-beta1 and IFN-beta3).
    Title: ICP27 protein encoded by bovine herpesvirus type 1 (bICP27) interferes with promoter activity of the bovine genes encoding beta interferon 1 (IFN-β1) and IFN-β3.
  4. The authors demonstrate that bovine herpesvirus 1 bICP0 effectively inhibits bovine IFN-beta promoter activity and induces IRF3 degradation.
    Title: Cytoplasmic localized infected cell protein 0 (bICP0) encoded by bovine herpesvirus 1 inhibits β interferon promoter activity and reduces IRF3 (interferon response factor 3) protein levels.
  5. These studies provide evidence that virus infection differentially stimulates expression of the three bovine IFN-beta genes.
    Title: Infection of cultured bovine cells with bovine herpesvirus 1 (BHV-1) or Sendai virus induces different beta interferon subtypes.
  6. recombinant bovine respiratory syncytial virus lacking the NS proteins, and those lacking NS2 in particular, are strong inducers of IFN-alpha/beta in bovine nasal fibroblasts and bronchoalveolar macrophages.
    Title: Role of alpha/beta interferons in the attenuation and immunogenicity of recombinant bovine respiratory syncytial viruses lacking NS proteins.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables type I interferon receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in B cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in T cell activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in humoral immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in natural killer cell activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to exogenous dsRNA IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interferon beta
Names
IFN-beta
interferon beta-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174350.1 → NP_776775.1  interferon beta precursor

    See identical proteins and their annotated locations for NP_776775.1

    Status: PROVISIONAL

    Source sequence(s)
    M15477
    UniProtKB/Swiss-Prot
    P01578
    UniProtKB/TrEMBL
    A0A7R8C3B6, A9QWQ3
    Conserved Domains (1) summary
    cl00092
    Location:27 → 177
    IFab; Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several ...

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    23263785..23264421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P01578.1 GenPept UniProtKB/Swiss-Prot:P01578

Gene LinkOut

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