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PRKACB protein kinase cAMP-activated catalytic subunit beta [ Bos taurus (cattle) ]

Gene ID: 282323, updated on 3-Apr-2024

Summary

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Official Symbol
PRKACBprovided by VGNC
Official Full Name
protein kinase cAMP-activated catalytic subunit betaprovided by VGNC
Primary source
VGNC:VGNC:33321
See related
Ensembl:ENSBTAG00000011953
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (59883281..60026111, complement)

Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene deoxyribonuclease 2 beta Neighboring gene urate oxidase Neighboring gene sterile alpha motif domain containing 13 Neighboring gene sterile alpha motif domain containing 13 Neighboring gene eukaryotic translation initiation factor 1-like pseudogene Neighboring gene tubulin tyrosine ligase like 7 Neighboring gene uncharacterized LOC132344888

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A cloned bovine cDNA encodes an alternate form of the catalytic subunit of cAMP-dependent protein kinase. Showers MO, et al. J Biol Chem, 1986 Dec 15. PMID 3023347
  2. Isoform C beta 2, an unusual form of the bovine catalytic subunit of cAMP-dependent protein kinase. Wiemann S, et al. J Biol Chem, 1991 Mar 15. PMID 2002051
  3. The amino terminus of PKA catalytic subunit--a site for introduction of posttranslational heterogeneities by deamidation: D-Asp2 and D-isoAsp2 containing isozymes. Kinzel V, et al. Protein Sci, 2000 Nov. PMID 11152138, Free PMC Article
  4. Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-stimulated AMP-activated protein kinase in endothelial cells. Jin BY, et al. Proc Natl Acad Sci U S A, 2009 Oct 13. PMID 19805165, Free PMC Article
  5. Identification, cloning and characterization of a novel 47 kDa murine PKA C subunit homologous to human and bovine Cbeta2. Funderud A, et al. BMC Biochem, 2006 Aug 4. PMID 16889664, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. critically involved in mediating the phosphorylation of AMP kinase promoted by hydrogen peroxide in endothelial cells.
    Title: Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-stimulated AMP-activated protein kinase in endothelial cells.
  2. Murine lymphoid tissues express a protein that is a homolog of bovine Cbeta2 (protein kinase c subunit beta2).
    Title: Identification, cloning and characterization of a novel 47 kDa murine PKA C subunit homologous to human and bovine Cbeta2.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cAMP-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein kinase A signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of cAMP-dependent protein kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cAMP-dependent protein kinase catalytic subunit beta
Names
PKA C-beta
protein kinase, cAMP-dependent, catalytic, beta
NP_777010.1
XP_005204430.2
XP_005204431.2
XP_005204432.2
XP_005204435.2
XP_010801671.2
XP_059737696.1
XP_059737704.1
XP_059737715.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174585.3 → NP_777010.1  cAMP-dependent protein kinase catalytic subunit beta

    See identical proteins and their annotated locations for NP_777010.1

    Status: PROVISIONAL

    Source sequence(s)
    J02647
    UniProtKB/Swiss-Prot
    P05131, P24256
    UniProtKB/TrEMBL
    A0A3Q1LUR5
    Conserved Domains (1) summary
    cd14209
    Location:42 → 331
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    59883281..60026111 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059881732.1 → XP_059737715.1  cAMP-dependent protein kinase catalytic subunit beta isoform X8

  2. XM_005204373.5 → XP_005204430.2  cAMP-dependent protein kinase catalytic subunit beta isoform X1

    UniProtKB/TrEMBL
    A0A3Q1LUR5, A0A452DJE2
    Related
    ENSBTAP00000046803.4, ENSBTAT00000050033.4
    Conserved Domains (1) summary
    cd14209
    Location:88 → 377
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  3. XM_010803369.4 → XP_010801671.2  cAMP-dependent protein kinase catalytic subunit beta isoform X6

    UniProtKB/TrEMBL
    A0A3Q1LUR5, A0A3Q1LVC4
    Related
    ENSBTAP00000066358.2, ENSBTAT00000077834.2
    Conserved Domains (1) summary
    cd14209
    Location:30 → 319
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  4. XM_059881713.1 → XP_059737696.1  cAMP-dependent protein kinase catalytic subunit beta isoform X4

  5. XM_005204374.5 → XP_005204431.2  cAMP-dependent protein kinase catalytic subunit beta isoform X2

    UniProtKB/TrEMBL
    A0A3Q1LUR5
    Conserved Domains (1) summary
    cd14209
    Location:46 → 335
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  6. XM_005204375.5 → XP_005204432.2  cAMP-dependent protein kinase catalytic subunit beta isoform X3

    UniProtKB/TrEMBL
    A0A3Q1LUR5, A6QNX4
    Related
    ENSBTAP00000062742.1, ENSBTAT00000080990.2
    Conserved Domains (1) summary
    cd14209
    Location:45 → 334
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

  7. XM_059881721.1 → XP_059737704.1  cAMP-dependent protein kinase catalytic subunit beta isoform X5

  8. XM_005204378.5 → XP_005204435.2  cAMP-dependent protein kinase catalytic subunit beta isoform X7

    UniProtKB/TrEMBL
    A0A3Q1LUR5, A0A452DJ97
    Related
    ENSBTAP00000060905.2, ENSBTAT00000074614.2
    Conserved Domains (1) summary
    cd14209
    Location:29 → 318
    STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05131.2 GenPept UniProtKB/Swiss-Prot:P05131

Gene LinkOut

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