TXNRD1 thioredoxin reductase 1 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: TXNRD1provided by VGNC
Official Full Name: thioredoxin reductase 1provided by VGNC
Primary source: VGNC:VGNC:36545
See related: Ensembl:ENSBTAG00000013912
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Summary: The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, May 2017]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	5	NC_037332.1 (67898938..67961974)

Chromosome 5 - NC_037332.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data provide evidence for the involvement of the Trx/TrxR system, in the regulation of haem oxygenase-1 expression in aortic endothelial cells during pro-oxidant challenge
Title: Thioredoxin reductase regulates the induction of haem oxygenase-1 expression in aortic endothelial cells.
These results suggest that thioredoxin reductase may act as a positive regulator of NF-kappa B and may play an important role in the cellular inflammatory response.
Title: Overexpression of thioredoxin reductase 1 regulates NF-kappa B activation.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info	PubMed
enables glutathione-disulfide reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info	PubMed
enables thioredoxin-disulfide reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info	PubMed
involved_in glutathione metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: thioredoxin reductase 1, cytoplasmic

Names: TR; peroxidase TXNRD1; thioredoxin reductase TR1

NP_777050.1

EC 1.11.1.2

EC 1.8.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174625.5 → NP_777050.1 thioredoxin reductase 1, cytoplasmic

See identical proteins and their annotated locations for NP_777050.1

Status: REVIEWED

Source sequence(s)

AF053984, CO896976

UniProtKB/Swiss-Prot

O62768

Related

ENSBTAP00000018473.7, ENSBTAT00000018473.7

Conserved Domains (3) summary

TIGR01438
Location:11 → 499

TGR; thioredoxin and glutathione reductase selenoprotein

pfam00070
Location:192 → 268

Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase

pfam02852
Location:371 → 481

Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain