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Slco1a6 solute carrier organic anion transporter family, member 1a6 [ Mus musculus (house mouse) ]

Gene ID: 28254, updated on 8-Feb-2024

Summary

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Official Symbol
Slco1a6provided by MGI
Official Full Name
solute carrier organic anion transporter family, member 1a6provided by MGI
Primary source
MGI:MGI:1351906
See related
Ensembl:ENSMUSG00000079262 AllianceGenome:MGI:1351906
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oatp5; Oatp-5; Slc21a13; 4930422F19Rik
Summary
Predicted to enable bile acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Acts upstream of or within several processes, including bile acid metabolic process; heme metabolic process; and lipid homeostasis. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in brain ventricle and choroid plexus; metanephros; and telencephalon ventricular layer. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward kidney adult (RPKM 11.4) See more
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Genomic context

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Location:
6 G2; 6 73.42 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142031487..142131903, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (142085761..142186177, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30843 Neighboring gene solute carrier organic anion transporter family, member 1a1 Neighboring gene solute carrier organic anion transporter family, member 1a8 Neighboring gene STARR-seq mESC enhancer starr_17699 Neighboring gene STARR-seq mESC enhancer starr_17700 Neighboring gene predicted gene, 18159 Neighboring gene STARR-seq mESC enhancer starr_17701 Neighboring gene predicted gene, 53313 Neighboring gene solute carrier organic anion transporter family, member 1a5 Neighboring gene STARR-seq mESC enhancer starr_17703 Neighboring gene islet amyloid polypeptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning, expression, and ontogeny of mouse organic anion-transporting polypeptide-5, a kidney-specific organic anion transporter. Choudhuri S, et al. Biochem Biophys Res Commun, 2001 Jan 12. PMID 11162483
  2. Identification of the Bile Acid Transporter Slco1a6 as a Candidate Gene That Broadly Affects Gene Expression in Mouse Pancreatic Islets. Tian J, et al. Genetics, 2015 Nov. PMID 26385979, Free PMC Article
  3. Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs. van de Steeg E, et al. J Clin Invest, 2010 Aug. PMID 20644253, Free PMC Article
  4. Molecular physiology of renal organic anion transporters. Sekine T, et al. Am J Physiol Renal Physiol, 2006 Feb. PMID 16403838
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results suggest that genetic variation in Slco1a6 leads to altered transport of taurocholic acid and potentially other bile acids) by pancreatic islets, resulting in broad gene regulation
    Title: Identification of the Bile Acid Transporter Slco1a6 as a Candidate Gene That Broadly Affects Gene Expression in Mouse Pancreatic Islets.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables bile acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in bile acid and bile salt transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within bile acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heme metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within xenobiotic metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier organic anion transporter family member 1A6
Names
kidney-specific organic anion-transporting polypeptide 5
organic anion-transporting polypeptide
solute carrier family (organic anion transporter) member 13
solute carrier family 21 (organic anion transporter), member 13
solute carrier family 21 member 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001381930.1 → NP_001368859.1  solute carrier organic anion transporter family member 1A6

    Status: VALIDATED

    Source sequence(s)
    AC134836, AK142587
    UniProtKB/Swiss-Prot
    Q3UQC6, Q99J94, Q9CUP7
    UniProtKB/TrEMBL
    Q6IR20
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter

  2. NM_023718.3 → NP_076207.1  solute carrier organic anion transporter family member 1A6

    See identical proteins and their annotated locations for NP_076207.1

    Status: VALIDATED

    Source sequence(s)
    AK142587, AK143970
    Consensus CDS
    CCDS39693.1
    UniProtKB/Swiss-Prot
    Q3UQC6, Q99J94, Q9CUP7
    UniProtKB/TrEMBL
    Q6IR20
    Related
    ENSMUSP00000107458.4, ENSMUST00000111827.4
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    142031487..142131903 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506965.3 → XP_006507028.1  solute carrier organic anion transporter family member 1A6 isoform X1

    See identical proteins and their annotated locations for XP_006507028.1

    UniProtKB/Swiss-Prot
    Q3UQC6, Q99J94, Q9CUP7
    UniProtKB/TrEMBL
    Q6IR20
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter

  2. XM_011241587.2 → XP_011239889.1  solute carrier organic anion transporter family member 1A6 isoform X1

    See identical proteins and their annotated locations for XP_011239889.1

    UniProtKB/Swiss-Prot
    Q3UQC6, Q99J94, Q9CUP7
    UniProtKB/TrEMBL
    Q6IR20
    Conserved Domains (1) summary
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99J94.1 GenPept UniProtKB/Swiss-Prot:Q99J94

Gene LinkOut

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