ATP5F1A ATP synthase F1 subunit alpha [Bos taurus (cattle)] - Gene

Summary

Official Symbol: ATP5F1Aprovided by VGNC
Official Full Name: ATP synthase F1 subunit alphaprovided by VGNC
Primary source: VGNC:VGNC:26299
See related: BGD:BT26659; Ensembl:ENSBTAG00000002507
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: ATP5A1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	24	NC_037351.1 (45841918..45850825, complement)

Chromosome 24 - NC_037351.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037351.1 Chromosome 24 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that bovine F-ATP synthase was capable to hydrolyze Ca2+-ATP.
Title: Purified F-ATP synthase forms a Ca(2+)-dependent high-conductance channel matching the mitochondrial permeability transition pore.
Combining cryoelectron microscopy data with bioinformatic analysis allowed the authors to determine the fold of the a subunit, suggesting a proton translocation path through the FO region that involves both the a and b subunits.
Title: Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM.
F1-ATPase at the cell surface of colonic epithelial cells has a role in mediating cell proliferation
Title: Identification of the F1-ATPase at the cell surface of colonic epithelial cells: role in mediating cell proliferation.
The beneficial effects of dietary resveratrol may derive in part by preventing mitochondrial ATP synthesis in tumor cells, thereby inducing apoptosis.
Title: Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols.
Nuclear magnetic resonance characterization of the interaction between OSCP-N terminal and a peptide corresponding to residues 1-25 of the alpha-subunit of bovine F(1)-ATPase is presented.
Title: How the N-terminal domain of the OSCP subunit of bovine F1Fo-ATP synthase interacts with the N-terminal region of an alpha subunit.

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General gene information

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Markers

D16S2555E (e-PCR)
- UniSTS:151643

MARC_6801-6802:992007470:1 (e-PCR)
- UniSTS:231273

MARC_5063-5064:996690101:1 (e-PCR)
- UniSTS:269447

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ADP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables proton-transporting ATP synthase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proton motive force-driven ATP synthesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of mitochondrial proton-transporting ATP synthase, catalytic core	IEA Inferred from Electronic Annotation more info	PubMed
part_of proton-transporting ATP synthase complex, catalytic core F(1)	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ATP synthase subunit alpha, mitochondrial

Names: ATP synthase alpha subunit; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.