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Sbsn suprabasin [ Mus musculus (house mouse) ]

Gene ID: 282619, updated on 5-Mar-2024

Summary

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Official Symbol
Sbsnprovided by MGI
Official Full Name
suprabasinprovided by MGI
Primary source
MGI:MGI:2446326
See related
Ensembl:ENSMUSG00000046056 AllianceGenome:MGI:2446326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110005D19Rik
Summary
Located in cytoplasm. Is expressed in several structures, including alimentary system; nose; and skin. Orthologous to human SBSN (suprabasin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 17.4), stomach adult (RPKM 9.3) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B1; 7 19.24 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30432099..30455559)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30732674..30756134)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9108 Neighboring gene ATPase, H+/K+ exchanging, gastric, alpha polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E11349 Neighboring gene transmembrane protein 147 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, spermatogenic Neighboring gene dermokine Neighboring gene keratinocyte differentiation associated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SBSN drives bladder cancer metastasis via EGFR/SRC/STAT3 signalling. Zhou Z, et al. Br J Cancer, 2022 Jul. PMID 35484216, Free PMC Article
  2. Interferon-regulated suprabasin is essential for stress-induced stem-like cell conversion and therapy resistance of human malignancies. Hubackova S, et al. Mol Oncol, 2019 Jul. PMID 30919591, Free PMC Article
  3. Suprabasin as a novel tumor endothelial cell marker. Alam MT, et al. Cancer Sci, 2014 Dec. PMID 25283635, Free PMC Article
  4. Suprabasin-null mice retain skin barrier function and show high contact hypersensitivity to nickel upon oral nickel loading. Nakazawa S, et al. Sci Rep, 2020 Sep 3. PMID 32884021, Free PMC Article
  5. Suprabasin, a novel epidermal differentiation marker and potential cornified envelope precursor. Park GT, et al. J Biol Chem, 2002 Nov 22. PMID 12228223, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SBSN drives bladder cancer metastasis via EGFR/SRC/STAT3 signalling.
    Title: SBSN drives bladder cancer metastasis via EGFR/SRC/STAT3 signalling.
  2. SBSN expression was observed in human clinical specimens of colon and ovarian carcinomas, as well as in circulating tumour cells and metastases of the 4T1 mouse model. The association of SBSN expression with progressive stages of cancer development indicates its role in cancer evolution and therapy resistance.
    Title: Interferon-regulated suprabasin is essential for stress-induced stem-like cell conversion and therapy resistance of human malignancies.
  3. Findings suggest that SBSN is involved in the angiogenic potential of tumor endothelial cells (TEC) and may be a novel TEC marker.
    Title: Suprabasin as a novel tumor endothelial cell marker.
  4. Sbsn, Dmkn and Krtdap are coordinately expressed during epidermal morphogenesis.
    Title: Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression.
  5. These results indicate that the suprabasin protein potentially plays a role in the process of epidermal differentiation.
    Title: Suprabasin, a novel epidermal differentiation marker and potential cornified envelope precursor.
  6. These results indicate that the suprabasin protein potentially plays a role in the process of epidermal differentiation
    Title: Suprabasin, a novel epidermal differentiation marker and potential cornified envelope precursor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
suprabasin
Names
suprabasal-specific protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083903.1 → NP_001077372.1  suprabasin isoform 2 precursor

    See identical proteins and their annotated locations for NP_001077372.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1 and lacks the repetitive central domain rich in glycine and alanine found in isoform 1.
    Source sequence(s)
    AI507307, BC051531
    Consensus CDS
    CCDS59725.1
    UniProtKB/TrEMBL
    A0A0R4J2A5, S4R2I1
    Related
    ENSMUSP00000138561.2, ENSMUST00000182229.8

  2. NM_172205.3 → NP_757342.2  suprabasin isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). The protein contains a repetitive central domain rich in glycine and alanine.
    Source sequence(s)
    AA791703, AC167978, AI507307
    Consensus CDS
    CCDS39891.1
    UniProtKB/TrEMBL
    E9QPB2
    Related
    ENSMUSP00000079362.6, ENSMUST00000080518.14
    Conserved Domains (1) summary
    pfam05262
    Location:462 → 600
    Borrelia_P83; Borrelia P83/100 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    30432099..30455559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242650.1 → XP_030098510.1  suprabasin isoform X1

    UniProtKB/TrEMBL
    E9QPB2
    Conserved Domains (1) summary
    pfam05262
    Location:462 → 600
    Borrelia_P83; Borrelia P83/100 protein

  2. XM_006540028.3 → XP_006540091.1  suprabasin isoform X2

    Conserved Domains (1) summary
    pfam05262
    Location:452 → 590
    Borrelia_P83; Borrelia P83/100 protein

  3. XM_006540029.2 → XP_006540092.1  suprabasin isoform X3

  4. XM_030242652.1 → XP_030098512.1  suprabasin isoform X4

    UniProtKB/TrEMBL
    A0A0R4J2A5, S4R2I1

  5. XM_030242651.1 → XP_030098511.1  suprabasin isoform X1

    UniProtKB/TrEMBL
    E9QPB2
    Conserved Domains (1) summary
    pfam05262
    Location:462 → 600
    Borrelia_P83; Borrelia P83/100 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CIT9.1 GenPept UniProtKB/Swiss-Prot:Q8CIT9

Gene LinkOut

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