Impa2 inositol monophosphatase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Impa2provided by RGD
Official Full Name: inositol monophosphatase 2provided by RGD
Primary source: RGD:628692
See related: Ensembl:ENSRNOG00000018516 AllianceGenome:RGD:628692
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable inositol monophosphate 1-phosphatase activity and protein homodimerization activity. Predicted to be involved in inositol metabolic process; inositol phosphate dephosphorylation; and signal transduction. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human IMPA2 (inositol monophosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 67.4), Thymus (RPKM 46.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (63104113..63135232)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (60834206..60867575)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (63016577..63050123)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables inositol monophosphate 1-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol monophosphate 1-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol monophosphate 1-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables inositol monophosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol monophosphate 4-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in inositol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in inositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in response to lithium ion	IEA Inferred from Electronic Annotation more info
involved_in response to lithium ion	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inositol monophosphatase 2

Names: IMP 2; IMPase 2; inositol (myo)-1(or 4)-monophosphatase 2; inositol-1(or 4)-monophosphatase 2; myo-inositol monophosphatase A2

NP_757378.1

EC 3.1.3.25

XP_038952536.1

EC 3.1.3.25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172224.1 → NP_757378.1 inositol monophosphatase 2

See identical proteins and their annotated locations for NP_757378.1

Status: PROVISIONAL

Source sequence(s)

AY160191

UniProtKB/Swiss-Prot

Q8CIN7

UniProtKB/TrEMBL

A6IXU0, A6IXU1

Related

ENSRNOP00000025147.4, ENSRNOT00000025147.6

Conserved Domains (1) summary

cd01639
Location:21 → 266

IMPase; inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

63104113..63135232

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039096608.2 → XP_038952536.1 inositol monophosphatase 2 isoform X1

UniProtKB/TrEMBL

A0A0G2JUN5

Related

ENSRNOP00000069164.2

Conserved Domains (1) summary

cd01639
Location:28 → 259

IMPase; inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled ...