U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GPR6 G protein-coupled receptor 6 [ Homo sapiens (human) ]

Gene ID: 2830, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
GPR6provided by HGNC
Official Full Name
G protein-coupled receptor 6provided by HGNC
Primary source
HGNC:HGNC:4515
See related
Ensembl:ENSG00000146360 MIM:600553; AllianceGenome:HGNC:4515
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable sphingosine-1-phosphate receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within positive regulation of cytosolic calcium ion concentration. Predicted to be integral component of plasma membrane. Predicted to be active in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GPR6 in Genome Data Viewer
Location:
6q21
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (109978311..109980720)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (111156757..111159166)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (110299514..110301923)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:109828991-109829516 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:109829517-109830042 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:109834827-109835332 Neighboring gene ZBTB24 divergent transcript Neighboring gene adenylate kinase 9 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:110000392-110001073 Neighboring gene MPRA-validated peak6018 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24932 Neighboring gene FIG4 phosphoinositide 5-phosphatase Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:110176827-110177342 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:110177343-110177858 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:110203046-110204245 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:110214364-110214978 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:110265029-110265927 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:110265928-110266825 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:110299945-110300750 Neighboring gene uncharacterized LOC107986631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24934 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:110437149-110437694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:110437695-110438238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17466 Neighboring gene WASP family member 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. GPR6 Structural Insights: Homology Model Construction and Docking Studies. Isawi IH, et al. Molecules, 2020 Feb 7. PMID 32046081, Free PMC Article
  2. How much of reinforcement learning is working memory, not reinforcement learning? A behavioral, computational, and neurogenetic analysis. Collins AG, et al. Eur J Neurosci, 2012 Apr. PMID 22487033, Free PMC Article
  3. Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. Uhlenbrock K, et al. Cell Physiol Biochem, 2003. PMID 12649592
  4. Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors. Song ZH, et al. Genomics, 1995 Jul 20. PMID 8530049
  5. Isolation of three novel human genes encoding G protein-coupled receptors. Heiber M, et al. DNA Cell Biol, 1995 Jan. PMID 7832990

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR6 Structural Insights: Homology Model Construction and Docking Studies.
    Title: GPR6 Structural Insights: Homology Model Construction and Docking Studies.
  2. The GPR6 gene influences the reinforcement learning rate in a computational, neurogenetic model.
    Title: How much of reinforcement learning is working memory, not reinforcement learning? A behavioral, computational, and neurogenetic analysis.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
  4. control of gene expression in vascular endothelial cells in the presence of fluid shear stress and determines that it is not a sphingosine 1-phosphate receptor
    Title: Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ59257

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables sphingosine-1-phosphate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingosine-1-phosphate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
G-protein coupled receptor 6
Names
sphingosine 1-phosphate receptor GPR6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286099.2 → NP_001273028.1  G-protein coupled receptor 6 isoform a

    See identical proteins and their annotated locations for NP_001273028.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and enocdes the longer isoform (a).
    Source sequence(s)
    AK295250, AL591076, BC043414, DA205492, DA260869
    Consensus CDS
    CCDS69172.1
    UniProtKB/TrEMBL
    E7EP76
    Related
    ENSP00000406986.2, ENST00000414000.3
    Conserved Domains (1) summary
    cd15962
    Location:88 → 355
    7tmA_GPR6; G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_005284.5 → NP_005275.1  G-protein coupled receptor 6 isoform b

    See identical proteins and their annotated locations for NP_005275.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AL591076, BC043414, DA205492, DA260869
    Consensus CDS
    CCDS5079.1
    UniProtKB/Swiss-Prot
    B4DHS9, J3KQR3, P46095, Q17RJ7, Q5SYL0
    UniProtKB/TrEMBL
    E7EP76, F1DAM6
    Related
    ENSP00000275169.3, ENST00000275169.5
    Conserved Domains (1) summary
    cd15962
    Location:73 → 340
    7tmA_GPR6; G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    109978311..109980720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    111156757..111159166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46095.1 GenPept UniProtKB/Swiss-Prot:P46095

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous