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HISLA HIF1A stabilizing long noncoding RNA [ Homo sapiens (human) ]

Gene ID: 283587, updated on 10-Oct-2023

Summary

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Official Symbol
HISLAprovided by HGNC
Official Full Name
HIF1A stabilizing long noncoding RNAprovided by HGNC
Primary source
HGNC:HGNC:49467
See related
Ensembl:ENSG00000258867 AllianceGenome:HGNC:49467
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LINC01146
Expression
Biased expression in liver (RPKM 4.5) and prostate (RPKM 1.5) See more
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Genomic context

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Location:
14q31.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (88024550..88087346)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (82245178..82307975)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (88490894..88553690)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_38639 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8834 Neighboring gene RNA, U6 small nuclear 835, pseudogene Neighboring gene long intergenic non-protein coding RNA 1147 Neighboring gene NANOG hESC enhancer GRCh37_chr14:88503612-88504113 Neighboring gene G protein-coupled receptor 65 Neighboring gene uncharacterized LOC107984699 Neighboring gene uncharacterized LOC105370612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8835 Neighboring gene potassium two pore domain channel subfamily K member 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Liver-specific LINC01146, a promising prognostic indicator, inhibits the malignant phenotype of hepatocellular carcinoma cells both in vitro and in vivo. Ma X, et al. J Transl Med, 2022 Jan 31. PMID 35101062, Free PMC Article
  2. Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells. Chen F, et al. Nat Cell Biol, 2019 Apr. PMID 30936474
  3. Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens. Rubicz R, et al. Genet Epidemiol, 2014 Jul. PMID 24962563, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Liver-specific LINC01146, a promising prognostic indicator, inhibits the malignant phenotype of hepatocellular carcinoma cells both in vitro and in vivo.
    Title: Liver-specific LINC01146, a promising prognostic indicator, inhibits the malignant phenotype of hepatocellular carcinoma cells both in vitro and in vivo.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Other Names

  • HIF-1alpha-stabilizing long noncoding RNA
  • long intergenic non-protein coding RNA 1146

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_046094.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL157955, BC029479
    Related
    ENST00000556033.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    88024550..88087346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    82245178..82307975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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