ZNF852 zinc finger protein 852 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF852provided by HGNC
Official Full Name: zinc finger protein 852provided by HGNC
Primary source: HGNC:HGNC:27713
See related: Ensembl:ENSG00000178917 AllianceGenome:HGNC:27713
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: suggests misassembly
Expression: Ubiquitous expression in prostate (RPKM 1.1), spleen (RPKM 1.0) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 3p21.31

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (44491766..44510617, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (44507580..44526413, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (44533258..44552109, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zinc finger protein 852 is essential for the proliferation, drug sensitivity, and self-renewal of gastric cancer cells.
Title: Zinc finger protein 852 is essential for the proliferation, drug sensitivity, and self-renewal of gastric cancer cells.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:487289

SHGC-34261 (e-PCR)
- UniSTS:75728

STS-R89287 (e-PCR)
- UniSTS:75729

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 852

Names: putative zinc finger protein 852

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001287349.3 → NP_001274278.1 zinc finger protein 852 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the same splice pattern as variant 1, but represents an alternate allele. This transcript lacks two nucleotides compared to GRCh38 to represent the variation reported by the rs36046723 SNP. The encoded isoform (3) has a frameshifted C-terminus, compared to isoform 1.

Source sequence(s)

AC099669, AK296954

UniProtKB/Swiss-Prot

Q6ZMS4
NM_001423469.1 → NP_001410398.1 zinc finger protein 852 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the allele encoded by the reference genome (GRCh38) and encodes isoform 1.

Source sequence(s)

AC099669

UniProtKB/Swiss-Prot

B4DLD7, Q6ZMS4

Related

ENSP00000389841.2, ENST00000436261.6
NM_001423470.1 → NP_001410399.1 zinc finger protein 852 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the allele encoded by the reference genome (GRCh38) and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is one amino acid longer than isoform 1.

Source sequence(s)

AC099669
NM_001423484.1 → NP_001410413.1 zinc finger protein 852 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents the same splice pattern as variant 2, but represents an alternate allele. This transcript lacks two nucleotides compared to GRCh38 to represent the variation reported by the rs36046723 SNP. The encoded isoform (4) has a frameshifted C-terminus, compared to isoform 2.

Source sequence(s)

AC099669, AK296954