U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GPRIN3 GPRIN family member 3 [ Homo sapiens (human) ]

Gene ID: 285513, updated on 7-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
GPRIN3provided by HGNC
Official Full Name
GPRIN family member 3provided by HGNC
Primary source
HGNC:HGNC:27733
See related
Ensembl:ENSG00000185477 MIM:611241; AllianceGenome:HGNC:27733
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRIN3
Summary
Predicted to be involved in neuron projection development. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in appendix (RPKM 5.7), lymph node (RPKM 5.4) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GPRIN3 in Genome Data Viewer
Location:
4q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (89236383..89307800, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (92567541..92638966, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (90157534..90228951, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 907, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr4:90074054-90074582 Neighboring gene uncharacterized LOC124900834 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15568 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15569 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:90340115-90340640 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:90340641-90341165 Neighboring gene uncharacterized LOC105377328 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:90410728-90411320 Neighboring gene NANOG hESC enhancer GRCh37_chr4:90432809-90433310 Neighboring gene uncharacterized LOC124900855 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:90462817-90463325

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. miR-6838-5p Affects Cell Growth, Migration, and Invasion by Targeting GPRIN3 via the Wnt/β-Catenin Signaling Pathway in Gastric Cancer. Zhou W, et al. Pathobiology, 2020. PMID 33254176
  2. Identification and biochemical analysis of GRIN1 and GRIN2. Iida N, et al. Methods Enzymol, 2004. PMID 15488195
  3. Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia. Tarabeux J, et al. Transl Psychiatry, 2011 Nov 15. PMID 22833210, Free PMC Article
  4. PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential. Yadav L, et al. iScience, 2020 Feb 21. PMID 32062451, Free PMC Article
  5. Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins. Dho SE, et al. Sci Rep, 2019 Aug 28. PMID 31462741, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-6838-5p Affects Cell Growth, Migration, and Invasion by Targeting GPRIN3 via the Wnt/beta-Catenin Signaling Pathway in Gastric Cancer.
    Title: miR-6838-5p Affects Cell Growth, Migration, and Invasion by Targeting GPRIN3 via the Wnt/β-Catenin Signaling Pathway in Gastric Cancer.
  2. Functional compensation could occur to counteract the loss of one allele in GRIN2C and GRIN3 family genes.
    Title: Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ42625

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
G protein-regulated inducer of neurite outgrowth 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198281.3 → NP_938022.2  G protein-regulated inducer of neurite outgrowth 3

    See identical proteins and their annotated locations for NP_938022.2

    Status: VALIDATED

    Source sequence(s)
    AC093862, AC105388
    Consensus CDS
    CCDS34030.1
    UniProtKB/Swiss-Prot
    Q6ZVF9, Q8IVE4
    UniProtKB/TrEMBL
    A0AVI5
    Related
    ENSP00000476603.1, ENST00000609438.2
    Conserved Domains (1) summary
    pfam15235
    Location:650 → 771
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    89236383..89307800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008044.2 → XP_016863533.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZVF9, Q8IVE4
    UniProtKB/TrEMBL
    A0AVI5
    Conserved Domains (1) summary
    pfam15235
    Location:650 → 771
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  2. XM_047450091.1 → XP_047306047.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZVF9, Q8IVE4

  3. XM_005262936.4 → XP_005262993.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

    See identical proteins and their annotated locations for XP_005262993.1

    UniProtKB/Swiss-Prot
    Q6ZVF9, Q8IVE4
    UniProtKB/TrEMBL
    A0AVI5
    Conserved Domains (1) summary
    pfam15235
    Location:650 → 771
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  4. XM_047450090.1 → XP_047306046.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZVF9, Q8IVE4

  5. XM_005262937.5 → XP_005262994.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

    See identical proteins and their annotated locations for XP_005262994.1

    UniProtKB/Swiss-Prot
    Q6ZVF9, Q8IVE4
    UniProtKB/TrEMBL
    A0AVI5
    Conserved Domains (1) summary
    pfam15235
    Location:650 → 771
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  6. XM_047450089.1 → XP_047306045.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZVF9, Q8IVE4

  7. XM_017008043.2 → XP_016863532.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZVF9, Q8IVE4
    UniProtKB/TrEMBL
    A0AVI5
    Conserved Domains (1) summary
    pfam15235
    Location:650 → 771
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  8. XM_047450093.1 → XP_047306049.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZVF9, Q8IVE4

  9. XM_047450092.1 → XP_047306048.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZVF9, Q8IVE4
    Related
    ENSP00000328672.3, ENST00000333209.4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    92567541..92638966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349731.1 → XP_054205706.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZVF9, Q8IVE4

  2. XM_054349730.1 → XP_054205705.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZVF9, Q8IVE4

  3. XM_054349729.1 → XP_054205704.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZVF9, Q8IVE4

  4. XM_054349726.1 → XP_054205701.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZVF9, Q8IVE4

  5. XM_054349728.1 → XP_054205703.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZVF9, Q8IVE4

  6. XM_054349727.1 → XP_054205702.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZVF9, Q8IVE4

  7. XM_054349732.1 → XP_054205707.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZVF9, Q8IVE4

RNA

  1. XR_007074276.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZVF9.2 GenPept UniProtKB/Swiss-Prot:Q6ZVF9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous