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C5orf60 chromosome 5 open reading frame 60 [ Homo sapiens (human) ]

Gene ID: 285679, updated on 10-Oct-2023

Summary

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Official Symbol
C5orf60provided by HGNC
Official Full Name
chromosome 5 open reading frame 60provided by HGNC
Primary source
HGNC:HGNC:27753
See related
Ensembl:ENSG00000204661 AllianceGenome:HGNC:27753
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: This locus is considered non-coding by other groups due to a lack of experimental support for the protein, but NCBI annotates the protein because it meets minimal RefSeq quality criteria for representation. The coding status remains uncertain. [09 Mar 2015]
Expression
Restricted expression toward testis (RPKM 6.8) See more
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Genomic context

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Location:
5q35.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (179641544..179645046, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (180194509..180196455, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (179068545..179072047, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC128966623 Neighboring gene RUN and FYVE domain containing 1 Neighboring gene RUFY1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:179033750-179034250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:179034251-179034751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23754 Neighboring gene Sharpr-MPRA regulatory region 11836 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:179051499-179052283 Neighboring gene heterogeneous nuclear ribonucleoprotein H1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:179059505-179060005 Neighboring gene chromosome 5 open reading frame 60-like Neighboring gene uncharacterized LOC105377763

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The DNA sequence and comparative analysis of human chromosome 5. Schmutz J, et al. Nature, 2004 Sep 16. PMID 15372022
  2. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528
  3. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. Faust TB, et al. Elife, 2018 May 30. PMID 29845934, Free PMC Article
  4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Clone Names

  • FLJ35723

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_131066.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC136604
    Related
    ENST00000625191.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    179641544..179645046 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_016107298.1 Reference GRCh38.p14 PATCHES

    Range
    413717..417220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    180194509..180196455 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013718.1: Suppressed sequence

    Description
    NM_001013718.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_001142306.2: Suppressed sequence

    Description
    NM_001142306.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  3. NM_001305388.1: Suppressed sequence

    Description
    NM_001305388.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NFR6.2 GenPept UniProtKB/Swiss-Prot:A6NFR6
Q8NA96.2 GenPept UniProtKB/Swiss-Prot:Q8NA96

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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