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CPA1 carboxypeptidase A1 [ Bos taurus (cattle) ]

Gene ID: 286762, updated on 5-Mar-2024

Summary

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Official Symbol
CPA1provided by VGNC
Official Full Name
carboxypeptidase A1provided by VGNC
Primary source
VGNC:VGNC:27642
See related
BGD:BT15758; Ensembl:ENSBTAG00000046169
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (94128595..94135228)

Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene serine rich single-pass membrane protein 1 Neighboring gene carboxypeptidase A4 Neighboring gene carboxypeptidase A5 Neighboring gene centrosomal protein 41 Neighboring gene microRNA mir-335 Neighboring gene mesoderm specific transcript

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Carboxypeptidase A-catalyzed direct conversion of leukotriene C4 to leukotriene F4. Reddanna P, et al. Arch Biochem Biophys, 2003 May 15. PMID 12729612
  2. Cloning, sequencing and expression of the gene encoding a major allotypic preprocarboxypeptidase A from bovine pancreas. Goo JH, et al. Gene, 1995 Nov 20. PMID 8522204
  3. The three-dimensional structure of the native ternary complex of bovine pancreatic procarboxypeptidase A with proproteinase E and chymotrypsinogen C. Gomis-Rüth FX, et al. EMBO J, 1995 Sep 15. PMID 7556081, Free PMC Article
  4. Refined crystal structure of carboxypeptidase A at 1.54 A resolution. Rees DC, et al. J Mol Biol, 1983 Aug 5. PMID 6887246
  5. Identification of the amino acid replacements characterizing the allotypic forms of bovine carboxypeptidase A. Pétra PH, et al. Biochemistry, 1969 Jul. PMID 5817619

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
carboxypeptidase A1
Names
carboxypeptidase A1 (pancreatic)
pancreatic procarboxypeptidase A
NP_777175.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174750.2 → NP_777175.1  carboxypeptidase A1 precursor

    See identical proteins and their annotated locations for NP_777175.1

    Status: PROVISIONAL

    Source sequence(s)
    M61851
    UniProtKB/Swiss-Prot
    P00730
    UniProtKB/TrEMBL
    A6H6Y4, F1MUG4
    Related
    ENSBTAP00000009745.4, ENSBTAT00000009745.5
    Conserved Domains (2) summary
    cd03870
    Location:117 → 417
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:27 → 99
    Propep_M14; Carboxypeptidase activation peptide

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    94128595..94135228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00730.3 GenPept UniProtKB/Swiss-Prot:P00730

Gene LinkOut

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Research Materials
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