Gnat3 G protein subunit alpha transducin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gnat3provided by RGD
Official Full Name: G protein subunit alpha transducin 3provided by RGD
Primary source: RGD:727817
See related: Ensembl:ENSRNOG00000005268 AllianceGenome:RGD:727817
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hg1e; gnat-3
Summary: Enables GTP binding activity and GTPase activity. Involved in response to nicotine. Located in acrosomal vesicle; apical plasma membrane; and axoneme. Orthologous to human GNAT3 (G protein subunit alpha transducin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 16.4), Liver (RPKM 8.7) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (18054551..18104332, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (17162500..17212283, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (13827764..13878126, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Morphology of GNAT3-immunoreactive chemosensory cells in the nasal cavity and pharynx of the rat.
Title: Morphology of GNAT3-immunoreactive chemosensory cells in the nasal cavity and pharynx of the rat.
Sweet taste molecules of T1R2, T1R3, alpha-gustducin and TRPM5 in ileum were dramatically higher than those in duodenum (P<0.01 for each).
Title: Expression of sweet taste receptor and gut hormone secretion in modelled type 2 diabetes.
The staining protocols, especially the fixation time, cause discrepancies in gustducin immunoreactivities.
Title: Fixation conditions affect the immunoreactivity of gustducin in rat vallate taste buds.
Data show that the positive expression of alpha-gustducin (Gnat3 protein in diabetic rat taste bud cells is higher than that in normal controls as shown by both immunohistochemistry and RT-PCR.
Title: Expression of alpha-gustducin in the circumvallate papillae of taste buds of diabetic rats.
The data suggest that gustducin is involved in signal transduction of all the tastes of sweet, umami, and bitter in the soft palate, in contrast to its limited function in the tongue.
Title: Expression of gustducin overlaps with that of type III IP3 receptor in taste buds of the rat soft palate.
Co-expression patterns of the neuropeptides vasoactive intestinal peptide and cholecystokinin with the transduction molecules alpha-gustducin and T1R2 in rat taste receptor cells
Title: Co-expression patterns of the neuropeptides vasoactive intestinal peptide and cholecystokinin with the transduction molecules alpha-gustducin and T1R2 in rat taste receptor cells.
Axonemal-associated localization within the midpiece and principal piece of rat spermatozoa raises the possibility that this G protein alpha-subunit may process intracellular signals controlling sperm motility.
Title: Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa.

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General gene information

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Markers

Gnat3 (e-PCR), detects polymorphism
- UniSTS:532431

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sensory perception of bitter taste	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sweet taste	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of sweet taste	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of taste	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of umami taste	ISO Inferred from Sequence Orthology more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	ISO Inferred from Sequence Orthology more info
is_active_in photoreceptor inner segment	IBA Inferred from Biological aspect of Ancestor more info
is_active_in photoreceptor outer segment	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: guanine nucleotide-binding protein G(t) subunit alpha-3

Names: guanine nucleotide binding protein, alpha transducing 3; gustducin alpha-3 chain; heterotrimeric guanine nucleotide-binding protein 1e

NP_775162.1

EC 2.3.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173139.2 → NP_775162.1 guanine nucleotide-binding protein G(t) subunit alpha-3

See identical proteins and their annotated locations for NP_775162.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

P29348

UniProtKB/TrEMBL

A6K5D8

Related

ENSRNOP00000007032.6, ENSRNOT00000007032.7

Conserved Domains (1) summary

cd00066
Location:34 → 348

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)