Abca5 ATP binding cassette subfamily A member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abca5provided by RGD
Official Full Name: ATP binding cassette subfamily A member 5provided by RGD
Primary source: RGD:628661
See related: Ensembl:ENSRNOG00000004378 AllianceGenome:RGD:628661
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in several processes, including cholesterol efflux; cholesterol homeostasis; and regulation of cholesterol transport. Located in Golgi apparatus. Orthologous to human ABCA5 (ATP binding cassette subfamily A member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 128.8), Brain (RPKM 80.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (95739610..95808633, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (95240159..95309195, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (98573226..98645028, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of rAbca5 mRNA in Leydig cells, intracellular localization of rAbca5-EGFP/rAbca5-V5 and involvement of rAbca5-related proteins in lipid transport suggest that rAbca5 may participate in intracellular sterol/steroid trafficking.
Title: Subcellular localization of rat Abca5, a rat ATP-binding-cassette transporter expressed in Leydig cells, and characterization of its splice variant apparently encoding a half-transporter.
Molecular cloning of Abca5.
Title: Cloning of human and rat ABCA5/Abca5 and detection of a human splice variant.

Submit: New GeneRIF Correction

General gene information

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Markers

RH143977 (e-PCR)
- UniSTS:233223

AI535109 (e-PCR)
- UniSTS:248084

AU048011 (e-PCR)
- UniSTS:109961

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipid transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in high-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in lipid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reverse cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reverse cholesterol transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in regulation of cholesterol efflux	ISS Inferred from Sequence or Structural Similarity more info
involved_in sterol transport	NAS Non-traceable Author Statement more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cholesterol transporter ABCA5

Names: ATP-binding cassette sub-family A member 5; ATP-binding cassette, sub-family A (ABC1), member 5; ATP-binding cassette, subfamily A (ABC1), member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173307.1 → NP_775429.1 cholesterol transporter ABCA5

See identical proteins and their annotated locations for NP_775429.1

Status: PROVISIONAL

Source sequence(s)

AJ426052

UniProtKB/Swiss-Prot

Q80Z07, Q8CF82

UniProtKB/TrEMBL

A6HKD1

Related

ENSRNOP00000005848.4, ENSRNOT00000005848.7

Conserved Domains (3) summary

cd03263
Location:478 → 701

ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A

COG1131
Location:1288 → 1615

CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]

pfam12698
Location:214 → 416

ABC2_membrane_3; ABC-2 family transporter protein