Bod1 biorientation of chromosomes in cell division 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bod1provided by RGD
Official Full Name: biorientation of chromosomes in cell division 1provided by RGD
Primary source: RGD:1305622
See related: Ensembl:ENSRNOG00000020717 AllianceGenome:RGD:1305622
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam44b; RGD1305622
Summary: Predicted to enable protein phosphatase 2A binding activity and protein phosphatase inhibitor activity. Predicted to be involved in mitotic sister chromatid segregation; negative regulation of phosphoprotein phosphatase activity; and protein localization to chromosome, centromeric region. Predicted to be located in chromosome; cytoplasm; and microtubule organizing center. Predicted to be part of outer kinetochore. Predicted to be active in centrosome; spindle microtubule; and spindle pole. Orthologous to several human genes including BOD1 (biorientation of chromosomes in cell division 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 130.6), Heart (RPKM 121.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (16497918..16504259)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (15993454..15999795)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (16259728..16266069)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid biorientation	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid cohesion, centromeric	ISO Inferred from Sequence Orthology more info
involved_in protein localization to chromosome, centromeric region	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Set1C/COMPASS complex	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of outer kinetochore	ISO Inferred from Sequence Orthology more info
located_in spindle microtubule	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: biorientation of chromosomes in cell division protein 1

Names: biorientation defective protein 1; family with sequence similarity 44, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013854.1 → NP_001013876.2 biorientation of chromosomes in cell division protein 1

See identical proteins and their annotated locations for NP_001013876.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the functional protein.

Source sequence(s)

BC079025

UniProtKB/TrEMBL

A0A0H2UHS5, A6HDC9

Related

ENSRNOP00000028115.5, ENSRNOT00000028115.5

Conserved Domains (1) summary

pfam05205
Location:107 → 200

COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

RNA

NR_073160.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

JAXUCZ010000010