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Rnf145 ring finger protein 145 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287212, updated on 30-Mar-2024

Summary

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Official Symbol
Rnf145provided by RGD
Official Full Name
ring finger protein 145provided by RGD
Primary source
RGD:1309561
See related
Ensembl:ENSRNOG00000004602 AllianceGenome:RGD:1309561
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309561
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human RNF145 (ring finger protein 145). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in Thymus (RPKM 310.4), Lung (RPKM 289.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (29507779..29552153)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (29006391..29050788)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (30169147..30207505)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene GINS complex subunit 4, pseudogene 1 Neighboring gene ubiquitin-like domain containing CTD phosphatase 1 Neighboring gene uncharacterized LOC120095078 Neighboring gene uncharacterized LOC120095081

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RING finger protein 145
NP_001099248.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105778.3 → NP_001099248.1  RING finger protein 145

    See identical proteins and their annotated locations for NP_001099248.1

    Status: VALIDATED

    Source sequence(s)
    BC168651, CA503504, JAXUCZ010000010
    UniProtKB/TrEMBL
    B5DEF7, F7F591
    Related
    ENSRNOP00000006436.5, ENSRNOT00000006436.6
    Conserved Domains (3) summary
    COG5243
    Location:520 → 643
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd16684
    Location:533 → 575
    RING-H2_RNF145; RING finger, H2 subclass, found in RING finger protein 145 (RNF145) and similar proteins
    pfam13705
    Location:8 → 506
    TRC8_N; TRC8 N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    29507779..29552153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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