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Arhgef15 Rho guanine nucleotide exchange factor 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287418, updated on 4-Apr-2024

Summary

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Official Symbol
Arhgef15provided by RGD
Official Full Name
Rho guanine nucleotide exchange factor 15provided by RGD
Primary source
RGD:1306961
See related
Ensembl:ENSRNOG00000004566 AllianceGenome:RGD:1306961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
E5
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in positive regulation of stress fiber assembly and regulation of catalytic activity. Located in cytoplasm. Orthologous to human ARHGEF15 (Rho guanine nucleotide exchange factor 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 69.9), Kidney (RPKM 61.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q24
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54149372..54162128, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (53650521..53663269, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (55532097..55545675, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene outer dense fiber of sperm tails 4 Neighboring gene ribosomal protein S4, X-linked, pseudogene 7 Neighboring gene uncharacterized LOC134480814 Neighboring gene solute carrier family 25, member 35 Neighboring gene RAN guanine nucleotide release factor Neighboring gene phosphoribosylformylglycinamidine synthase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells. Ogita H, et al. Circ Res, 2003 Jul 11. PMID 12775584
  2. EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation. Margolis SS, et al. Cell, 2010 Oct 29. PMID 21029865, Free PMC Article
  3. Genome-wide identification of endothelial cell-enriched genes in the mouse embryo. Takase H, et al. Blood, 2012 Jul 26. PMID 22535667
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of synapse maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stress fiber assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within retina vasculature morphogenesis in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 15
Names
Rho guanine nucleotide exchange factor (GEF) 15
ephexin-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414295.2 → NP_001401224.1  rho guanine nucleotide exchange factor 15

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0G2JTU0
    Related
    ENSRNOP00000068844.1, ENSRNOT00000084385.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    54149372..54162128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085436.2 → XP_038941364.1  rho guanine nucleotide exchange factor 15 isoform X1

    Conserved Domains (2) summary
    smart00325
    Location:390 → 566
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:590 → 710
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain

RNA

  1. XR_005489733.2 RNA Sequence

  2. XR_005489734.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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