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Camta2 calmodulin binding transcription activator 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287462, updated on 13-Apr-2024

Summary

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Official Symbol
Camta2provided by RGD
Official Full Name
calmodulin binding transcription activator 2provided by RGD
Primary source
RGD:1311296
See related
Ensembl:ENSRNOG00000004283 AllianceGenome:RGD:1311296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including DNA binding activity; histone deacetylase binding activity; and transcription coactivator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cardiac muscle hypertrophy in response to stress and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. Orthologous to human CAMTA2 (calmodulin binding transcription activator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 80.4), Kidney (RPKM 64.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q24
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55882071..55900575, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (55383450..55401838, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57291192..57309638, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene profilin 1 Neighboring gene enolase 3 Neighboring gene sperm associated antigen 7 Neighboring gene inhibitor of CDK, cyclin A1 interacting protein 1 Neighboring gene small nucleolar RNA U3 Neighboring gene kinesin family member 1C Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor. Long C, et al. Proc Natl Acad Sci U S A, 2014 Aug 5. PMID 25049392, Free PMC Article
  2. The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases. Song K, et al. Cell, 2006 May 5. PMID 16678093
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calmodulin-binding transcription activator 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105801.2 → NP_001099271.2  calmodulin-binding transcription activator 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6GE51
    Related
    ENSRNOP00000086530.1, ENSRNOT00000109888.1
    Conserved Domains (5) summary
    smart01076
    Location:34 → 150
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    cd00204
    Location:712 → 810
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01833
    Location:535 → 615
    TIG; IPT/TIG domain
    pfam13637
    Location:712 → 776
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:711 → 754
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    55882071..55900575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597100.3 → XP_017452589.1  calmodulin-binding transcription activator 2 isoform X5

    UniProtKB/TrEMBL
    A0A8I6GE51, D3ZLG1
    Related
    ENSRNOP00000053461.4

  2. XM_039085484.2 → XP_038941412.1  calmodulin-binding transcription activator 2 isoform X2

    UniProtKB/TrEMBL
    A6HG91
    Conserved Domains (5) summary
    PTZ00322
    Location:767 → 906
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    smart01076
    Location:57 → 173
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    sd00045
    Location:734 → 777
    ANK; ANK repeat [structural motif]
    pfam01833
    Location:558 → 638
    TIG; IPT/TIG domain
    pfam12796
    Location:739 → 831
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_039085486.2 → XP_038941414.1  calmodulin-binding transcription activator 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZPC9
    Conserved Domains (5) summary
    PTZ00322
    Location:767 → 906
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    smart01076
    Location:57 → 173
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    sd00045
    Location:734 → 777
    ANK; ANK repeat [structural motif]
    pfam01833
    Location:558 → 638
    TIG; IPT/TIG domain
    pfam12796
    Location:739 → 831
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_039085487.1 → XP_038941415.1  calmodulin-binding transcription activator 2 isoform X6

    UniProtKB/TrEMBL
    A0A8I6GE51
    Conserved Domains (5) summary
    PTZ00322
    Location:743 → 882
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    sd00045
    Location:710 → 753
    ANK; ANK repeat [structural motif]
    pfam01833
    Location:534 → 614
    TIG; IPT/TIG domain
    pfam12796
    Location:715 → 807
    Ank_2; Ankyrin repeats (3 copies)
    cl04295
    Location:57 → 149
    CG-1; CG-1 domain

  5. XM_039085483.1 → XP_038941411.1  calmodulin-binding transcription activator 2 isoform X1

    UniProtKB/TrEMBL
    A6HG91
    Conserved Domains (5) summary
    PTZ00322
    Location:772 → 911
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    smart01076
    Location:57 → 178
    CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
    sd00045
    Location:739 → 782
    ANK; ANK repeat [structural motif]
    pfam01833
    Location:563 → 643
    TIG; IPT/TIG domain
    pfam12796
    Location:744 → 836
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_063268663.1 → XP_063124733.1  calmodulin-binding transcription activator 2 isoform X7

  7. XM_063268662.1 → XP_063124732.1  calmodulin-binding transcription activator 2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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