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Krt17 keratin 17 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287702, updated on 11-Apr-2024

Summary

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Official Symbol
Krt17provided by RGD
Official Full Name
keratin 17provided by RGD
Primary source
RGD:1303181
See related
Ensembl:ENSRNOG00000026371 AllianceGenome:RGD:1303181
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ka17
Summary
Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including hair follicle morphogenesis; positive regulation of hair follicle development; and positive regulation of translation. Predicted to act upstream of or within intermediate filament organization; keratinization; and morphogenesis of an epithelium. Predicted to be located in cell periphery; cytoplasm; and intermediate filament cytoskeleton. Human ortholog(s) of this gene implicated in ectodermal dysplasia; pachyonychia congenita; and steatocystoma multiplex. Orthologous to human KRT17 (keratin 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 385.5) See more
Orthologs
human mouse all
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Genomic context

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Location:
10q31
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (85679068..85683792, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85178673..85183392, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88158993..88163712, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene type I keratin KA11 Neighboring gene keratin 16 Neighboring gene keratin 42 Neighboring gene uncharacterized LOC134480873

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Keratin 17 null mice exhibit age- and strain-dependent alopecia. McGowan KM, et al. Genes Dev, 2002 Jun 1. PMID 12050118, Free PMC Article
  2. A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Kim S, et al. Nature, 2006 May 18. PMID 16710422
  3. Keratin 16 and keratin 17 mutations cause pachyonychia congenita. McLean WH, et al. Nat Genet, 1995 Mar. PMID 7539673
  4. HLA DR B1*04, *07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis. Shen Z, et al. J Dermatol Sci, 2005 Apr. PMID 15795121
  5. Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. Saunders SP, et al. J Allergy Clin Immunol, 2013 Nov. PMID 24084074, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hair follicle morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in hair follicle morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intermediate filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in intermediate filament-based process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within keratinization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within morphogenesis of an epithelium ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hair follicle development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
  
is_active_in cornified envelope ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intermediate filament TAS
Traceable Author Statement
more info
 PubMed 
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in keratin filament TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
keratin, type I cytoskeletal 17
Names
CK-17
K17
cytokeratin-17
keratin 17, type I
type I keratin KA17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212545.2 → NP_997710.1  keratin, type I cytoskeletal 17

    See identical proteins and their annotated locations for NP_997710.1

    Status: PROVISIONAL

    Source sequence(s)
    BC100058
    UniProtKB/Swiss-Prot
    Q6IFU8
    UniProtKB/TrEMBL
    A0A0G2K9Q9, A6HJ20
    Related
    ENSRNOP00000005382.5, ENSRNOT00000005382.7
    Conserved Domains (2) summary
    pfam00038
    Location:84 → 394
    Filament; Intermediate filament protein
    cl14876
    Location:215 → 296
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    85679068..85683792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268733.1 → XP_063124803.1  keratin, type I cytoskeletal 17 isoform X1

  2. XM_039085609.1 → XP_038941537.1  keratin, type I cytoskeletal 17 isoform X2

    Conserved Domains (1) summary
    pfam00038
    Location:25 → 312
    Filament; Intermediate filament protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IFU8.1 GenPept UniProtKB/Swiss-Prot:Q6IFU8

Gene LinkOut

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