Lyzl6 lysozyme-like 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lyzl6provided by RGD
Official Full Name: lysozyme-like 6provided by RGD
Primary source: RGD:1306968
See related: Ensembl:ENSRNOG00000003501 AllianceGenome:RGD:1306968
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lyzb; RGD1306968
Summary: Predicted to enable lysozyme activity. Predicted to be involved in defense response to bacterium and fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in sperm midpiece and sperm plasma membrane. Predicted to be active in acrosomal vesicle and sperm flagellum. Orthologous to human LYZL6 (lysozyme like 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 38.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (89044375..89049210, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (88544342..88549177, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (91694547..91701428, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study indicates a role for LYZL6 protein in sperm function
Title: Immunization against lysozyme-like proteins affect sperm function and fertility in the rat.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lysozyme activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in fertilization	ISO Inferred from Sequence Orthology more info
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in acrosomal vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in sperm flagellum	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info
located_in sperm plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysozyme-like protein 6

Names: lysozyme b

NP_001129305.2

EC 3.2.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135833.1 → NP_001129305.2 lysozyme-like protein 6 precursor

See identical proteins and their annotated locations for NP_001129305.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A077S6M4, A0A9K3Y7P2, D3ZSK1

Related

ENSRNOP00000004650.5, ENSRNOT00000004650.5

Conserved Domains (1) summary

cd00119
Location:22 → 143

LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...