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Scarf2 scavenger receptor class F, member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287949, updated on 11-Apr-2024

Summary

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Official Symbol
Scarf2provided by RGD
Official Full Name
scavenger receptor class F, member 2provided by RGD
Primary source
RGD:1306013
See related
Ensembl:ENSRNOG00000000288 AllianceGenome:RGD:1306013
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable scavenger receptor activity. Predicted to be involved in endocytosis. Predicted to act upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Human ortholog(s) of this gene implicated in Van den Ende-Gupta syndrome. Orthologous to human SCARF2 (scavenger receptor class F member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 141.4), Uterus (RPKM 59.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
11q23
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96680237..96691686, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83175956..83187415, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87722350..87733734)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene protein FAM246A-like Neighboring gene carbonic anhydrase 15 Neighboring gene kelch-like family member 22 Neighboring gene large ribosomal subunit protein eL31-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SREC-II, a new member of the scavenger receptor type F family, trans-interacts with SREC-I through its extracellular domain. Ishii J, et al. J Biol Chem, 2002 Oct 18. PMID 12154095
  2. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables scavenger receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables scavenger receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
scavenger receptor class F member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105864.1 → NP_001099334.1  scavenger receptor class F member 2 precursor

    See identical proteins and their annotated locations for NP_001099334.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473999
    UniProtKB/TrEMBL
    A0A8I6AH58, A6JSK2
    Related
    ENSRNOP00000091964.1, ENSRNOT00000095028.1
    Conserved Domains (1) summary
    PHA03247
    Location:678 → 832
    PHA03247; large tegument protein UL36; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    96680237..96691686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088079.2 → XP_038944007.1  scavenger receptor class F member 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AH58
    Conserved Domains (2) summary
    PHA03247
    Location:619 → 773
    PHA03247; large tegument protein UL36; Provisional
    NF033759
    Location:114 → 367
    exchanger_TraA; outer membrane exchange protein TraA

  2. XM_039088078.2 → XP_038944006.1  scavenger receptor class F member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AH58, D3ZBQ5
    Related
    ENSRNOP00000000313.6
    Conserved Domains (2) summary
    PHA03247
    Location:683 → 837
    PHA03247; large tegument protein UL36; Provisional
    NF033759
    Location:74 → 431
    exchanger_TraA; outer membrane exchange protein TraA
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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