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Mtx2 metaxin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288150, updated on 5-Mar-2024

Summary

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Official Symbol
Mtx2provided by RGD
Official Full Name
metaxin 2provided by RGD
Primary source
RGD:1306473
See related
Ensembl:ENSRNOG00000001559 AllianceGenome:RGD:1306473
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in mitochondrion organization. Predicted to be located in mitochondrion and nucleolus. Predicted to be part of SAM complex. Predicted to be active in cytoplasm. Orthologous to human MTX2 (metaxin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 165.3), Testes (RPKM 127.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q23
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (80137556..80199547)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (59730206..59792202)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (61756109..61818999)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene homeo box D1 Neighboring gene uncharacterized LOC134486290 Neighboring gene uncharacterized LOC134486383 Neighboring gene uncharacterized LOC134486384

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Assembly of β-barrel proteins in the mitochondrial outer membrane. Höhr AI, et al. Biochim Biophys Acta, 2015 Jan. PMID 25305573
  2. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. Guarani V, et al. Elife, 2015 May 21. PMID 25997101, Free PMC Article
  3. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. Popiolek M, et al. J Biol Chem, 2011 Aug 19. PMID 21700703, Free PMC Article
  4. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC106000

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in mitochondrial transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SAM complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SAM complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
metaxin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008286.1 → NP_001008287.1  metaxin-2

    See identical proteins and their annotated locations for NP_001008287.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086360
    UniProtKB/TrEMBL
    A0A8I6APV3, F7FAZ7, Q5U1Z9
    Related
    ENSRNOP00000002134.4, ENSRNOT00000002134.6
    Conserved Domains (3) summary
    cd03211
    Location:125 → 250
    GST_C_Metaxin2; C-terminal, alpha helical domain of Metaxin 2
    COG0625
    Location:33 → 251
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03079
    Location:22 → 95
    GST_N_Metaxin2; GST_N family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a yeast two-hybrid system using metaxin 1 as the bait. Metaxin 2 shares sequence similarity with metaxin 1 but does not contain a C-terminal mitochondrial outer ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    80137556..80199547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234371.5 → XP_006234433.1  metaxin-2 isoform X2

    Conserved Domains (2) summary
    cd03079
    Location:22 → 95
    GST_N_Metaxin2; GST_N family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a yeast two-hybrid system using metaxin 1 as the bait. Metaxin 2 shares sequence similarity with metaxin 1 but does not contain a C-terminal mitochondrial outer ...
    cl02776
    Location:125 → 213
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

  2. XM_006234370.5 → XP_006234432.1  metaxin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZLV1, A0A8I5ZX94
    Related
    ENSRNOP00000078996.1
    Conserved Domains (3) summary
    cd03211
    Location:122 → 247
    GST_C_Metaxin2; C-terminal, alpha helical domain of Metaxin 2
    COG0625
    Location:30 → 248
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03079
    Location:19 → 92
    GST_N_Metaxin2; GST_N family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a yeast two-hybrid system using metaxin 1 as the bait. Metaxin 2 shares sequence similarity with metaxin 1 but does not contain a C-terminal mitochondrial outer ...

  3. XM_039104413.2 → XP_038960341.1  metaxin-2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6APV3
    Conserved Domains (2) summary
    cd03211
    Location:76 → 201
    GST_C_Metaxin2; C-terminal, alpha helical domain of Metaxin 2
    pfam10568
    Location:1 → 113
    Tom37; Outer mitochondrial membrane transport complex protein

  4. XM_039104412.2 → XP_038960340.1  metaxin-2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6APV3
    Conserved Domains (2) summary
    cd03211
    Location:76 → 201
    GST_C_Metaxin2; C-terminal, alpha helical domain of Metaxin 2
    pfam10568
    Location:1 → 113
    Tom37; Outer mitochondrial membrane transport complex protein
Nucleotide Protein Strain
Heading Accession and Version

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