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Naca nascent polypeptide associated complex subunit alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 288770, updated on 13-Apr-2024

Summary

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Official Symbol
Nacaprovided by RGD
Official Full Name
nascent polypeptide associated complex subunit alphaprovided by RGD
Primary source
RGD:1308642
See related
Ensembl:ENSRNOG00000002632 AllianceGenome:RGD:1308642
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable TBP-class protein binding activity; transcription coactivator activity; and unfolded protein binding activity. Predicted to be involved in several processes, including heart development; negative regulation of striated muscle cell apoptotic process; and positive regulation of skeletal muscle tissue growth. Predicted to act upstream of or within myoblast migration. Predicted to be located in nucleus. Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytoplasm. Orthologous to human NACA (nascent polypeptide associated complex subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 363.8), Spleen (RPKM 353.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1053474..1066606)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (468862..481992)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2458283..2470674)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene 17-beta-hydroxysteroid dehydrogenase type 6-like Neighboring gene transfer RNA proline (anticodon GGG) Neighboring gene DNA primase subunit 1 Neighboring gene prostaglandin E synthase 3 Neighboring gene uncharacterized LOC120093524 Neighboring gene small nucleolar RNA, C/D box 59A Neighboring gene ATP synthase F1 subunit beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. skNAC depletion stimulates myoblast migration and perturbs sarcomerogenesis by enhancing calpain 1 and 3 activity. Berkholz J, et al. Biochem J, 2013 Jul 15. PMID 23662692
  2. The alpha chain of the nascent polypeptide-associated complex functions as a transcriptional coactivator. Yotov WV, et al. Mol Cell Biol, 1998 Mar. PMID 9488445, Free PMC Article
  3. skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration. Park CY, et al. Proc Natl Acad Sci U S A, 2010 Nov 30. PMID 21071677, Free PMC Article
  4. The sclerostin-bone protein interactome. Devarajan-Ketha H, et al. Biochem Biophys Res Commun, 2012 Jan 13. PMID 22206666, Free PMC Article
  5. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cardiac ventricle development ISO
Inferred from Sequence Orthology
more info
  
involved_in heart development ISO
Inferred from Sequence Orthology
more info
  
involved_in heart trabecula morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within myoblast migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of striated muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell proliferation involved in heart morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of skeletal muscle tissue growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of skeletal muscle fiber development ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle tissue regeneration ISO
Inferred from Sequence Orthology
more info
  
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nascent polypeptide-associated complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nascent polypeptide-associated complex subunit alpha
Names
nascent polypeptide-associated complex alpha subunit
nascent-polypeptide-associated complex alpha polypeptide
NP_001099409.1
NP_001185491.1
NP_001185509.1
XP_038934468.1
XP_038934469.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105939.2 → NP_001099409.1  nascent polypeptide-associated complex subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_001099409.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2KAT8, B2RYX0
    Related
    ENSRNOP00000075523.2, ENSRNOT00000085092.2
    Conserved Domains (2) summary
    cd14415
    Location:169 → 214
    UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
    cd22054
    Location:84 → 131
    NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit

  2. NM_001198562.2 → NP_001185491.1  nascent polypeptide-associated complex subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_001185491.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2KAT8, B2RYX0
    Related
    ENSRNOP00000003550.6, ENSRNOT00000003550.8
    Conserved Domains (2) summary
    cd14415
    Location:169 → 214
    UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
    cd22054
    Location:84 → 131
    NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit

  3. NM_001198580.1 → NP_001185509.1  nascent polypeptide-associated complex subunit alpha isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an additional large exon in the CDS compared to variant 1. The resulting isoform (2) has a larger internal segment compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    M0R9L0
    Related
    ENSRNOP00000066181.1, ENSRNOT00000075681.4
    Conserved Domains (3) summary
    PHA03247
    Location:1075 → 1517
    PHA03247; large tegument protein UL36; Provisional
    cd14415
    Location:2117 → 2162
    UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
    cd22054
    Location:2032 → 2079
    NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    1053474..1066606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078540.2 → XP_038934468.1  nascent polypeptide-associated complex subunit alpha isoform X1

    UniProtKB/TrEMBL
    M0R9L0
    Conserved Domains (3) summary
    PHA03247
    Location:1075 → 1517
    PHA03247; large tegument protein UL36; Provisional
    cd14415
    Location:2117 → 2162
    UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
    cd22054
    Location:2032 → 2079
    NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit

  2. XM_039078541.2 → XP_038934469.1  nascent polypeptide-associated complex subunit alpha isoform X1

    UniProtKB/TrEMBL
    M0R9L0
    Conserved Domains (3) summary
    PHA03247
    Location:1075 → 1517
    PHA03247; large tegument protein UL36; Provisional
    cd14415
    Location:2117 → 2162
    UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
    cd22054
    Location:2032 → 2079
    NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit
Nucleotide Protein Strain
Heading Accession and Version

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