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Rbms2 RNA binding motif, single stranded interacting protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288771, updated on 3-Apr-2024

Summary

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Official Symbol
Rbms2provided by RGD
Official Full Name
RNA binding motif, single stranded interacting protein 2provided by RGD
Primary source
RGD:1304813
See related
Ensembl:ENSRNOG00000003076 AllianceGenome:RGD:1304813
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol and nucleus. Orthologous to human RBMS2 (RNA binding motif single stranded interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 129.6), Heart (RPKM 94.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q11
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1145240..1201690, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (560787..603881, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2550524..2592533, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD59 Neighboring gene small nucleolar RNA, C/D box 59A Neighboring gene ATP synthase F1 subunit beta Neighboring gene bromodomain adjacent to zinc finger domain, 2A Neighboring gene glutaminase 2 Neighboring gene SPRY domain containing 4 Neighboring gene major intrinsic protein of lens fiber

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(U) RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding motif, single-stranded-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025403.1 → NP_001020574.1  RNA-binding motif, single-stranded-interacting protein 2

    See identical proteins and their annotated locations for NP_001020574.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097377
    UniProtKB/TrEMBL
    A0A8I6A6C0, Q4QR81
    Related
    ENSRNOP00000086945.1, ENSRNOT00000118787.1
    Conserved Domains (2) summary
    cd12471
    Location:49 → 132
    RRM1_MSSP2; RNA recognition motif 1 (RRM1) found in vertebrate single-stranded DNA-binding protein MSSP-2
    cd12474
    Location:133 → 218
    RRM2_MSSP2; RNA recognition motif 2 (RRM2) found in vertebrate single-stranded DNA-binding protein MSSP-2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    1145240..1201690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263087.1 → XP_063119157.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X2

    UniProtKB/TrEMBL
    Q4QR81

  2. XM_063263086.1 → XP_063119156.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X2

    UniProtKB/TrEMBL
    Q4QR81

  3. XM_006240744.5 → XP_006240806.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006240806.1

    Conserved Domains (2) summary
    cd12474
    Location:105 → 190
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
    cl17169
    Location:19 → 104
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. XM_063263084.1 → XP_063119154.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYJ7

  5. XM_039078542.2 → XP_038934470.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A6C0, Q4QR81
    Conserved Domains (2) summary
    cd12471
    Location:49 → 132
    RRM1_MSSP2; RNA recognition motif 1 (RRM1) found in vertebrate single-stranded DNA-binding protein MSSP-2
    cd12474
    Location:133 → 218
    RRM2_MSSP2; RNA recognition motif 2 (RRM2) found in vertebrate single-stranded DNA-binding protein MSSP-2

  6. XM_063263085.1 → XP_063119155.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYJ7

  7. XM_039078544.2 → XP_038934472.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X5

    UniProtKB/TrEMBL
    A0A8I6A6C0, F7EVG9
    Related
    ENSRNOP00000043168.4
    Conserved Domains (2) summary
    cd12471
    Location:49 → 132
    RRM1_MSSP2; RNA recognition motif 1 (RRM1) found in vertebrate single-stranded DNA-binding protein MSSP-2
    cd12474
    Location:133 → 218
    RRM2_MSSP2; RNA recognition motif 2 (RRM2) found in vertebrate single-stranded DNA-binding protein MSSP-2

  8. XM_039078543.2 → XP_038934471.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A6C0
    Conserved Domains (2) summary
    cd12471
    Location:49 → 132
    RRM1_MSSP2; RNA recognition motif 1 (RRM1) found in vertebrate single-stranded DNA-binding protein MSSP-2
    cd12474
    Location:133 → 218
    RRM2_MSSP2; RNA recognition motif 2 (RRM2) found in vertebrate single-stranded DNA-binding protein MSSP-2

  9. XM_008765023.4 → XP_008763245.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X4

    See identical proteins and their annotated locations for XP_008763245.1

    Conserved Domains (2) summary
    cd12474
    Location:105 → 190
    RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
    cl17169
    Location:19 → 104
    RRM_SF; RNA recognition motif (RRM) superfamily

  10. XM_039078546.2 → XP_038934474.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X7

    Conserved Domains (1) summary
    cl17169
    Location:14 → 52
    RRM_SF; RNA recognition motif (RRM) superfamily

  11. XM_063263088.1 → XP_063119158.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X8

  12. XM_039078545.2 → XP_038934473.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X6

    Conserved Domains (2) summary
    cd12471
    Location:49 → 132
    RRM1_MSSP2; RNA recognition motif 1 (RRM1) found in vertebrate single-stranded DNA-binding protein MSSP-2
    cl17169
    Location:133 → 179
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. XR_010052944.1 RNA Sequence

  2. XR_001838668.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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