Bloc1s1 biogenesis of lysosomal organelles complex-1, subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bloc1s1provided by RGD
Official Full Name: biogenesis of lysosomal organelles complex-1, subunit 1provided by RGD
Primary source: RGD:1307564
See related: Ensembl:ENSRNOG00000007784 AllianceGenome:RGD:1307564
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in several processes, including anterograde synaptic vesicle transport; lysosome localization; and peptidyl-lysine acetylation. Predicted to be located in cytosol; early endosome; and mitochondrion. Predicted to be part of BLOC-1 complex and BORC complex. Orthologous to human BLOC1S1 (biogenesis of lysosomal organelles complex 1 subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 503.5), Muscle (RPKM 440.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (1931985..1935614, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (1347495..1351103, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (3342630..3346238, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of GCN5L1 activity under hyperglycemic conditions impairs cardiac energy metabolism.
Title: Loss of GCN5L1 in cardiac cells limits mitochondrial respiratory capacity under hyperglycemic conditions.
Acetylation of cardiac mitochondrial fatty acid oxidation enzymes by GCN5L1 significantly upregulates their activity in diet-induced obese mice.
Title: Acetylation of mitochondrial proteins by GCN5L1 promotes enhanced fatty acid oxidation in the heart.
NGF receptor signaling induces histone acetyltransferase domain-dependent nuclear translocation of PCAF and hGCN5 acetyltransferases
Title: Nerve growth factor receptor signaling induces histone acetyltransferase domain-dependent nuclear translocation of p300/CREB-binding protein-associated factor and hGCN5 acetyltransferases.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in aerobic respiration	ISO Inferred from Sequence Orthology more info
involved_in aerobic respiration	ISS Inferred from Sequence or Structural Similarity more info
involved_in anterograde axonal transport	ISO Inferred from Sequence Orthology more info
involved_in anterograde axonal transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in anterograde synaptic vesicle transport	ISO Inferred from Sequence Orthology more info
involved_in anterograde synaptic vesicle transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in endosomal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in lysosome localization	ISO Inferred from Sequence Orthology more info
involved_in lysosome localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of BLOC-1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of BLOC-1 complex	IEA Inferred from Electronic Annotation more info
part_of BLOC-1 complex	ISO Inferred from Sequence Orthology more info
part_of BLOC-1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of BORC complex	ISO Inferred from Sequence Orthology more info
part_of BORC complex	ISS Inferred from Sequence or Structural Similarity more info
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: biogenesis of lysosome-related organelles complex 1 subunit 1

Names: BLOC-1 subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105941.2 → NP_001099411.2 biogenesis of lysosome-related organelles complex 1 subunit 1

See identical proteins and their annotated locations for NP_001099411.2

Status: VALIDATED

Source sequence(s)

CB613801, CF979060

UniProtKB/Swiss-Prot

D3ZKU7

UniProtKB/TrEMBL

A0A8I6AE76

Related

ENSRNOP00000010380.4, ENSRNOT00000010380.8

Conserved Domains (1) summary

pfam06320
Location:5 → 117

GCN5L1; GCN5-like protein 1 (GCN5L1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

1931985..1935614 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263092.1 → XP_063119162.1 biogenesis of lysosome-related organelles complex 1 subunit 1 isoform X1

UniProtKB/TrEMBL

A6KSK8
XM_063263093.1 → XP_063119163.1 biogenesis of lysosome-related organelles complex 1 subunit 1 isoform X1

UniProtKB/TrEMBL

A6KSK8