Rchy1 ring finger and CHY zinc finger domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rchy1provided by RGD
Official Full Name: ring finger and CHY zinc finger domain containing 1provided by RGD
Primary source: RGD:1359180
See related: Ensembl:ENSRNOG00000002546 AllianceGenome:RGD:1359180
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pirh2
Summary: Enables signaling receptor binding activity. Predicted to be involved in cellular protein metabolic process and positive regulation of cellular protein metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Biomarker of sciatic neuropathy. Orthologous to human RCHY1 (ring finger and CHY zinc finger domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 225.7), Muscle (RPKM 224.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (16397533..16413286)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (16113263..16129017)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (17615968..17631715)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pirh2 may be a negative regulator of p27(kip1) and associated with glial proliferation.
Title: Changes in Pirh2 and p27kip1 expression following traumatic brain injury in adult rats.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in rescue of stalled ribosome	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RING finger and CHY zinc finger domain-containing protein 1

Names: ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase

NP_001007619.1

EC 2.3.2.27

XP_038947603.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007618.1 → NP_001007619.1 RING finger and CHY zinc finger domain-containing protein 1

See identical proteins and their annotated locations for NP_001007619.1

Status: PROVISIONAL

Source sequence(s)

BC083739

UniProtKB/TrEMBL

A0A8I5ZWY8, A6KKB6, A6KKB7, F7F3N3, Q5XIE4

Related

ENSRNOP00000003470.3, ENSRNOT00000003470.5

Conserved Domains (3) summary

pfam05495
Location:20 → 93

zf-CHY; CHY zinc finger

pfam13639
Location:144 → 186

zf-RING_2; Ring finger domain

pfam14599
Location:191 → 249

zinc_ribbon_6; Zinc-ribbon

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

16397533..16413286

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091675.1 → XP_038947603.1 RING finger and CHY zinc finger domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

A6KKC0

Conserved Domains (2) summary

cd16464
Location:17 → 60

RING-H2_Pirh2; RING finger, H2 subclass, found in p53-induced RING-H2 protein (Pirh2) and similar proteins

pfam14599
Location:64 → 122

zinc_ribbon_6; Zinc-ribbon