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Pold2 DNA polymerase delta 2, accessory subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 289758, updated on 6-Jun-2024

Summary

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Official Symbol
Pold2provided by RGD
Official Full Name
DNA polymerase delta 2, accessory subunitprovided by RGD
Primary source
RGD:1304954
See related
Ensembl:ENSRNOG00000014098 AllianceGenome:RGD:1304954
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity. Involved in DNA-dependent DNA replication. Part of delta DNA polymerase complex. Orthologous to human POLD2 (DNA polymerase delta 2, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 74.8), Heart (RPKM 70.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pold2 in Genome Data Viewer
Location:
14q21
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (84962933..84969148, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (80748971..80755188, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (86111416..86117578, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene DNA polymerase mu Neighboring gene AE binding protein 1 Neighboring gene uncharacterized LOC108352788 Neighboring gene myosin light chain 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A mutation detected in DNA polymerase delta cDNA from Novikoff hepatoma cells correlates with abnormal catalytic properties of the enzyme. Popanda O, et al. J Cancer Res Clin Oncol, 1999 Nov. PMID 10541966
  2. A novel PDIP1-related protein, KCTD10, that interacts with proliferating cell nuclear antigen and DNA polymerase delta. Zhou J, et al. Biochim Biophys Acta, 2005 Jul 10. PMID 15982757
  3. DNA polymerases and repair synthesis in NER in human cells. Lehmann AR. DNA Repair (Amst), 2011 Jul 15. PMID 21601536
  4. Calmodulin is involved in the induction of DNA polymerases alpha and delta activities in normal rat kidney cells activated to proliferate. López-Girona A, et al. Biochem Biophys Res Commun, 1995 Dec 14. PMID 7503737
  5. Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta. Ducoux M, et al. J Biol Chem, 2001 Dec 28. PMID 11595739

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA strand elongation involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in error-prone translesion synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in error-prone translesion synthesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of delta DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of delta DNA polymerase complex IC
Inferred by Curator
more info
 PubMed 
part_of delta DNA polymerase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of delta DNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of delta DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of zeta DNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of zeta DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA polymerase delta subunit 2
Names
DAN polymerase delta 2, accessory subunit
DNA polymerase delta subunit p50
DNA-directed DNA polymerase delta 2
polymerase (DNA directed), delta 2, accessory subunit
polymerase (DNA directed), delta 2, regulatory subunit
polymerase (DNA) delta 2, accessory subunit
NP_001013068.1
XP_063129020.1
XP_063129021.1
XP_063129022.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013050.1 → NP_001013068.1  DNA polymerase delta subunit 2

    See identical proteins and their annotated locations for NP_001013068.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079267
    UniProtKB/Swiss-Prot
    Q6AXY4
    UniProtKB/TrEMBL
    A0A8L2QAQ7, A6IKQ3
    Related
    ENSRNOP00000019288.4, ENSRNOT00000019288.5
    Conserved Domains (2) summary
    cd07387
    Location:215 → 452
    MPP_PolD2_C; PolD2 (DNA polymerase delta, subunit 2), C-terminal domain
    pfam18018
    Location:49 → 175
    DNA_pol_D_N; DNA polymerase delta subunit OB-fold domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    84962933..84969148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272951.1 → XP_063129021.1  DNA polymerase delta subunit 2 isoform X1

    UniProtKB/TrEMBL
    A0A8L2R542

  2. XM_063272952.1 → XP_063129022.1  DNA polymerase delta subunit 2 isoform X2

    UniProtKB/Swiss-Prot
    Q6AXY4
    UniProtKB/TrEMBL
    A0A8L2QAQ7, A6IKQ3

  3. XM_063272950.1 → XP_063129020.1  DNA polymerase delta subunit 2 isoform X1

    UniProtKB/TrEMBL
    A0A8L2R542
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AXY4.1 GenPept UniProtKB/Swiss-Prot:Q6AXY4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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