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Psmd6 proteasome 26S subunit, non-ATPase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289924, updated on 3-Apr-2024

Summary

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Symbol
Psmd6provided by RGD
Full Name
proteasome 26S subunit, non-ATPase 6provided by RGD
Primary source
RGD:735127
See related
Ensembl:ENSRNOG00000006751 AllianceGenome:RGD:735127
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
P44s10
Summary
Predicted to enable enzyme regulator activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome regulatory particle. Orthologous to human PSMD6 (proteasome 26S subunit, non-ATPase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 651.3), Heart (RPKM 562.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
15p16
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (13532675..13542682)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (11102174..11112180)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (12407557..12416153)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene enolase 1, pseudogene 18 Neighboring gene olfactory receptor family 2 subfamily T member 6 Neighboring gene ataxin 7 Neighboring gene NADH:ubiquinone oxidoreductase subunit A5, pseudogene 1 Neighboring gene uncharacterized LOC134481947

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mapping the murine cardiac 26S proteasome complexes. Gomes AV, et al. Circ Res, 2006 Aug 18. PMID 16857966
  2. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Wang X, et al. Biochemistry, 2007 Mar 20. PMID 17323924
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC72968

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of proteasome accessory complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome regulatory particle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
26S proteasome non-ATPase regulatory subunit 6
Names
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
proteasome regulatory particle subunit p44S10
proteasome, 26S, non-ATPase regulatory subunit 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198730.3 → NP_942025.1  26S proteasome non-ATPase regulatory subunit 6

    See identical proteins and their annotated locations for NP_942025.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    F7FGV7, Q6PCT9
    Conserved Domains (1) summary
    COG5187
    Location:15 → 382
    RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    13532675..13542682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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